Protein Alignment PEK and eif2ak3

DIOPT Version :10

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_031751151.1
• Gene: eif2ak3 / 100190763
• XenbaseID: XB-GENE-989849
• Length: 1133
• Species: Xenopus tropicalis
• Alignment Length: 1264
• Identity: 409/1264 - (32%)
• Similarity: 612/1264 - (48%)
• Gaps: 263/1264 - (20%)

  Fly    15 SLSFLQIVTLTMAGLVAFD-PAQVLAGHPTTDSELQTAG-------SPR----PPG------LEH 61
            |:..|.:|....|||:..: |....||:|..:.:.|:|.       ||.    |.|      :|.
 Frog    14 SVLTLLLVKAASAGLLEQEAPGSDAAGYPWEERDEQSAAGSSLSSLSPAAAAFPAGEVTVEDVES 78

  Fly    62 CVDQ-------EERRVARRLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSIHRLELTNN 119
            ..:|       :|.|.:|.|:.|||||||::|||....|:.:|.:..|.|.|:|||:.:.|:..|
 Frog    79 GTEQDYPEGGKDELRPSRSLVIISTLDGRIAALDAENHGRKQWDLDIGSGSLVSSSLSKPEVFGN 143

  Fly   120 GQFVRMIPSLSGGIYKFDGD--SIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSVRTGQL 182
            ..   :||||.|.::::|.|  |::.:|.|.|.||.||.||.||:|:.|||...:||:|..||::
 Frog   144 KM---IIPSLDGDLFQWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSATTGKV 205

  Fly   183 LYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVIIVRRQTQTV 247
            .|.||..||....|            ||.:|                     ||::::.|:.:||
 Frog   206 KYICSAMGCRRWNE------------DESEQ---------------------DDILLLHRKQKTV 237

  Fly   248 RAVESRTGVERWNFSVGQHELDL---VRPS----ECQLQPR------------DELELAVLDVDI 293
            |||..|:|.|:||||||..||..   :.|.    |.||:|.            |:.|:...|:.|
 Frog   238 RAVGPRSGSEKWNFSVGHFELRYIPDIEPGVGFIEGQLEPSYSTDESRIISDGDDQEVGTNDLAI 302

  Fly   294 KVVVPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADDELQPIDLFSSAQWLWDQD--ENDTE 356
            ||.|.:..:.||::.... :.|:::|..||.|||... :.::.||.||....:..|.:  |::.:
 Frog   303 KVSVADWKVMAFNRKLGH-LEWEHQFCTPIASAWLVR-NGKVVPISLFDDTSYTSDDEIFEDEED 365

  Fly   357 LPNAPQ--SPPSIYLGMYDKQLYIQESIRLRQEIMDQTKVYQQLTGDTSL--MPRIPWKP-ISAS 416
            |..|.:  :..|.||||:..|||:|.|:|:.::...........|.|.::  :|||.||| |.:.
 Frog   366 LVEAARGATESSFYLGMFRGQLYLQSSVRISEKFPVNPTALDTRTKDNAIISLPRIKWKPLIHSP 430

  Fly   417 SKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDENFAVAAQSVLNASEFVNGNGFYFYTTGDLNG 481
            |::.|:...|:.|..:..:          .:..|.::..|.|||.            |....|.|
 Frog   431 SRTPVLVGSDEFDKCLSND----------KFSHEEYSNGALSVLQ------------YPYAKLEG 473

  Fly   482 PQECSTQNNPTDL-------------PAITA------PTSPTNATSEGTEATGNHSVNDDLGFSL 527
            ......|..|..:             ||:|.      |.........||:.|.....|.    :.
 Frog   474 NPRLIQQRTPRQIVVPVISAGQSVHTPALTTDNGYYLPYYKRERNKRGTQITVGILENP----NY 534

  Fly   528 DDIDAPVKVVILSLWFWWKEIV-----VIAFTSAVILNIFM-GQRNQRVEREYLVIERHVPVQTA 586
            .:|.....|::|   .||||||     .|..|:.::..:|. ...|.|..:|         .:|.
 Frog   535 KNIRKKDPVLLL---HWWKEIVGTILFCITATTYIVRKLFQPNLTNARKRKE---------SETQ 587

  Fly   587 IEATEASTQALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSGEHYTSRFQSDFELMQCLGRG 651
            .: |::...|:.|.:                  :...|:..|..   |.||:.:|||.:||||||
 Frog   588 CQ-TDSKYDAINGDL------------------KDNFSDYQTFG---YVSRYLTDFEPIQCLGRG 630

  Fly   652 GFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQ 716
            ||||||||:||:|:..||||||.|||:|.:|::|:||.:.||..||..|||||::|.|.||..||
 Frog   631 GFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPELWQ 695

  Fly   717 EEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKE------KRQQQLLSWVSDAANSTACSHDFH 775
            |:.| :||..:.||...:.:|  :.:..|:.:::.      |.|.:::: .|::.:|.:.:. ..
 Frog   696 EKMD-ELLLKDGSTDWPLSSP--TPLDGLSVKVRSVDPYSMKEQVEVIT-PSESYSSLSAAF-VA 755

  Fly   776 LPG----ESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDD---YEEDEEQQGDHE 833
            :||    .||.:..|..:..:|..|:|:..:....|........||.|:.   ||.......|..
 Frog   756 VPGIGEQASSRRQSRASHTLNESSDALVNLQDSCLSDCELDHSSDDDDNHGIWYEHCPRTAADIG 820

  Fly   834 KRHRSSVSIDIHSASFDLKNINYSQH-------QLVSNSFQIESVRPKSSGSDDANDDNKARRKP 891
            ...|:|.||....:..|    |.|.|       .||.||    ....:.||:.|:|:.     ||
 Frog   821 VHERTSSSIVFEDSGCD----NSSNHVDKAEVSVLVMNS----EFSERESGTKDSNES-----KP 872

  Fly   892 LTLALAQNHNNNQNGSQPTPSSATI-LNGTVA---KPS--KVYLYIQMQLCRKESLRDWLR---- 946
            .:::....       |.|.|.|..: |:...|   ||:  ||||||||||||||:|:||:.
 Frog   873 TSISTLSE-------SPPRPKSLCLDLSKNTAESIKPTSPKVYLYIQMQLCRKENLKDWMSARCT 930

  Fly   947 -DNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPN 1010
             :.|.:|.:.|   :|.||.:||.::|.|||:|||||||||||:.|..:|:|||||||.|
 Frog   931 LEERPQTESLH---VFLQIAEAVQFLHSKGLMHRDLKPSNIFFTLDDVVKVGDFGLVTAM----- 987

  Fly  1011 LVAKCGDQ--------SGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYF 1067
                  ||        :.:|:.||||.||||.|||||||:.||.|.:||||:|||||.|||...|
 Frog   988 ------DQEEDEEAVLTPMPAYARHTGQVGTKLYMSPEQIFGQSYSHKVDIFSLGLILFELLYPF 1046

  Fly  1068 STEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQLRNILQLPHLLS 1132
            ||:|||::.|..|||.::|:.|...|..:.:::..|:|..|.:||:.::       |::.|...|
 Frog  1047 STQMERVRVLTELRDLKFPQLFTERYSTEQNMVLHMISHNPNERPEAEE-------IIENPLFDS 1104

  Fly  1133 EGQSEQAELAERARRLSRS--RTFSSSSE 1159
            .....:..|.:|:|.||.|  :||..||:
 Frog  1105 IDLHGKLALRQRSRTLSASGIKTFRQSSK 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874	118/352 (34%)
		Protein Kinases, catalytic domain	635..1113	CDD:473864	204/516 (40%)
eif2ak3	XP_031751151.1	Luminal_EIF2AK3	97..412	CDD:188874	118/352 (34%)
		STKc_EIF2AK3_PERK	615..1099	CDD:270950	206/529 (39%)
		Protein Kinases, catalytic domain	<909..982	CDD:473864	41/75 (55%)