DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PEK and pkr3

DIOPT Version :9

Sequence 1:	NP_649538.1	Gene:	PEK / 40653	FlyBaseID:	FBgn0037327	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_031758368.1	Gene:	pkr3 / 100141483	XenbaseID:	XB-GENE-12565119	Length:	534	Species:	Xenopus tropicalis

Alignment Length:	699	Identity:	151/699 - (21%)
Similarity:	225/699 - (32%)	Gaps:	318/699 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 QNNPTDLPAITAPTSPTNATS-----EGTEATGNHSVNDDLGFSLDDIDAPVKVVILSLWFWWKE 547
            |.||   |....||:..:..:     :|:.||...|||......:..|:
Frog    72 QENP---PLAQQPTAAASLDTGLSPLQGSAATAEPSVNGSENHKMSSIN---------------- 117

  Fly   548 IVVIAFTSAVILNIFMGQRNQRVERE--------------------YLVIE---RHVPVQTAIEA 589
                          ::|..|:..:::                    |.|.|   |..|.......
Frog   118 --------------YIGILNELCQKKSWSRNFRDVDRYGPDHEPKFYCVAEVNKREYPEGWGKNK 168

  Fly   590 TEASTQA---------------LLGPVVP--------------MQRPGNRFSFPPGQANQRT--- 622
            .:|..:|               :|.|.:|              .:..|||........|..|
Frog   169 KQARKKAAFLALRLLKTENPDDILIPAIPTAYTGESGSESSSVSESNGNRSIERRSLGNGATQVI 233

  Fly   623 --ISESTTHSGEHYTSRFQS---DFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSR 682
              ::|.:.|..:...:..||   :||.:..|..||||.||:|...:|:..||:|::.:.|
Frog   234 SAVTERSPHRTQSTANFVQSPLWEFEDITKLSTGGFGKVFKALKTMDKKYYAVKKVKMRN----- 293

  Fly   683 QRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTE 747
            ::...|.:.|||.:|.||||||||||.              :.:.|.||....|
Frog   294 EKCKLEVQALASLDHPNIVRYFHSWTG--------------MDYSLDTSYSCST----------- 333

  Fly   748 QLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRA 812

Frog   334 ----------------------------------------------------------------- 333

  Fly   813 EEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSG 877
                                                                          ||.
Frog   334 --------------------------------------------------------------SSN 336

  Fly   878 SDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRKESLR 942
            :|..|:                                            ||:|||:.|....|:
Frog   337 TDGMNE--------------------------------------------YLFIQMEFCENGDLK 357

  Fly   943 DWLRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMAD 1007
            :|:|..:...:...: :||.|||:.|.|:|.:.||||||||:||||::|.::||||.||||.||.
Frog   358 NWIRKMKIVDKVKSL-NIFRQIVEGVLYIHSEKLIHRDLKPANIFFAKDMRVKIGDLGLVTQMAS 421

  Fly  1008 IPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQH---YDYKVDIYSLGLIFFELHVYFST 1069
            ..:..|           ...|..:||..||:||    ||   |:.:|||::||||..||...|.|
Frog   422 EESTEA-----------LLRTHDIGTPSYMAPE----QHENIYNCEVDIFALGLILVELLCIFGT 471

  Fly  1070 EMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLK 1118
            |.||....:.:|:.|.|:.|...||.:...::.|||..|::||...:||
Frog   472 EHERYVEWKKIRNCQLPETFVAKYPYEICTIKLMLSRDPKKRPTATKLK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		PKc_like	635..1113	CDD:304357	116/483 (24%)
		S_TKc	<925..1118	CDD:214567	77/195 (39%)
pkr3	XP_031758368.1	DSRM_RNAse_III_family	3..69	CDD:380682
		DSRM_SF	117..183	CDD:412133	9/95 (9%)
		PKc_like	257..523	CDD:419665	117/481 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010