DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12147 and HRR25

DIOPT Version :9

Sequence 1:	NP_649536.1	Gene:	CG12147 / 40651	FlyBaseID:	FBgn0037325	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_015120.1	Gene:	HRR25 / 855897	SGDID:	S000006125	Length:	494	Species:	Saccharomyces cerevisiae

Alignment Length:	502	Identity:	187/502 - (37%)
Similarity:	270/502 - (53%)	Gaps:	108/502 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EIIVAGKYRLLKRIGNGSFGELFQAEGLKYHEKVAIKLESSTVKHPLLPREARIYGILQGGLGIP 125
            ::.|..|:|:.::||:||||:::....|...|:|||||||...:||.|..|:|:|..|.||:|||
Yeast     2 DLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRSRHPQLDYESRVYRYLSGGVGIP 66

  Fly   126 HVKHYATEGAYNVMVMDLLGPTLEDLLNLCSRSFSMKTTLMLADQILARVELLHRRCFIHRDIKP 190
            .::.:..||.||.||:|||||:||||.|.|.|.||.||.:|||.|:..|::.:|.|.||||||||
Yeast    67 FIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKP 131

  Fly   191 DNFLMGLNRHQTQVYMIDFGLAKKFYSLRTQKHIGYTENRDLVGTARYASVRAHYA-EQSRRDDL 254
            ||||||:.|..:.|::|||||:||:....|.:||.|.||:.|.||||||||..|.. ||||||||
Yeast   132 DNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDL 196

  Fly   255 ESVGYLLLYFQRGRLPWQGIRAQSQAQKYEKIAEYKANIPLQQLCSGLPVEFFMYLKYCRKLHFA 319
            ||:||:|:||.:|.|||||::|.::.|||::|.|.|.|:.::.||||||:||..|:.||:.|.|.
Yeast   197 ESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFD 261

  Fly   320 EKPDYVYLQQLFKVL-----FRNQYKVCDFLFDWVVLKRESPEQQSQQKGRERDRGGKRNVVVQK 379
            |||||::|.:|||.|     :.|     |.||||.:|:......:.|           |:::::|
Yeast   262 EKPDYLFLARLFKDLSIKLEYHN-----DHLFDWTMLRYTKAMVEKQ-----------RDLLIEK 310

  Fly   380 ERHRNKDRDSDTQRCRIKNGGD----------LLEIE---------ENESTTGEDPNEDKPQK-- 423
                 .|.::::......|..|          ||.::         :||......|.|.|.|.
Yeast   311 -----GDLNANSNAASASNSTDNKSETFNKIKLLAMKKFPTHFHYYKNEDKHNPSPEEIKQQTIL 370

  Fly   424 KHGKACSCSYHL---------------------------QKKRLQDRDR-------RAPLMTERR 454
            .:..|.|....|                           |.::||.:..       ..||:.:::
Yeast   371 NNNAASSLPEELLNALDKGMENLRQQQPQQQVQSSQPQPQPQQLQQQPNGQRPNYYPEPLLQQQQ 435

  Fly   455 ILSGEQEQELEL--------------------------ELRGSPQMP 475
            ..|.||:|::.:                          ::|.:||.|
Yeast   436 RDSQEQQQQVPMATTRATQYPPQINSNNFNTNQASVPPQMRSNPQQP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12147	NP_649536.1	STKc_CK1	67..331	CDD:270918	145/264 (55%)
CG12147	NP_649536.1	SPS1	67..>306	CDD:223589	132/239 (55%)
HRR25	NP_015120.1	PKc_like	8..282	CDD:419665	149/273 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I2253
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S180
OMA	1	1.010	-	-		QHG54222
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.730