DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12147 and Vrk3

DIOPT Version :9

Sequence 1:	NP_649536.1	Gene:	CG12147 / 40651	FlyBaseID:	FBgn0037325	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001005561.2	Gene:	Vrk3 / 361565	RGDID:	1549692	Length:	462	Species:	Rattus norvegicus

Alignment Length:	274	Identity:	73/274 - (26%)
Similarity:	117/274 - (42%)	Gaps:	39/274 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 GELFQAEGLKYHEKVAIKLESSTVKH----PLLPREARIYGILQGGLGIPHVKHYATEGAYNVMV 140
            |.||..:  .:.::.|..|:.:..|.    |||.....|      |.|:...|       |..:|
  Rat   197 GRLFNEQ--NFFQRAAKPLQVNKWKKRCLTPLLAIPTCI------GFGVHQDK-------YRFLV 246

  Fly   141 MDLLGPTLEDLLNLCSRS-FSMKTTLMLADQILARVELLHRRCFIHRDIKPDNFLMGLNRHQTQV 204
            ...||.:|:..|:...:. .|.:..|.:|.::|..:|.||...::|.::..:|..:. ....:||
  Rat   247 FPSLGRSLQSALDDNPKHVVSERCMLQVACRLLDALEYLHEHEYVHGNLTTENVFVN-PEDLSQV 310

  Fly   205 YMIDFGLAKKFYSLRTQKHIGYTE-NRDL-VGTARYASVRAHY-AEQSRRDDLESVGYLLLYFQR 266
            .::.:|...::  ....||:.|.| :|.| .|...:.|:..|. ...|||.||:::||.:|.:..
  Rat   311 TLVGYGFTYRY--CPGGKHVAYKEGSRSLHDGDLEFISMDVHKGCGPSRRSDLQTLGYCMLKWLY 373

  Fly   267 GRLPWQGI-----RAQSQAQKYEKIAEYKANIPLQQLC---SGLPVEFFMYLKYCRKLHFAEKPD 323
            |.|||...     ....|.|||:...|     ||..||   :........|||....|.:.|||.
  Rat   374 GSLPWTNCLPNTEEITKQKQKYQDNPE-----PLVGLCGRWNKTSETLREYLKVVMALDYEEKPP 433

  Fly   324 YVYLQQLFKVLFRN 337
            |..|:...:||.:|
  Rat   434 YATLRNNLEVLLQN 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12147	NP_649536.1	STKc_CK1	67..331	CDD:270918	70/266 (26%)
CG12147	NP_649536.1	SPS1	67..>306	CDD:223589	61/241 (25%)
Vrk3	NP_001005561.2	zinc_ribbon_2	13..35	CDD:289981
		DZR	14..>38	CDD:289539
		PKc_like	143..445	CDD:304357	71/270 (26%)
		SPS1	229..>458	CDD:223589	64/240 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900