DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12147 and Ttbk2

DIOPT Version :9

Sequence 1:	NP_649536.1	Gene:	CG12147 / 40651	FlyBaseID:	FBgn0037325	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	XP_006234899.2	Gene:	Ttbk2 / 311349	RGDID:	1311661	Length:	1311	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	150/542 - (27%)
Similarity:	227/542 - (41%)	Gaps:	132/542 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KDDRRWQGRSDVHQSKPQIRKERRHPPQPNHPHEKD------QRQDRRFSEEKQSLPEIIVAG-- 66
            |:...|            :|:|..:....|||.|.|      ..|....|...:. |:|:..|
  Rat    34 KETHSW------------LRREVGNRLNGNHPWELDACVAVLPHQCFAMSGGGEQ-PDILSVGIL 85

  Fly    67 ---KYRLLKRIGNGSFGELFQAEGLKYHEKVAIKLESSTVKHPLLPREARIYGILQGGLGIPHVK 128
               ::::|::||.|.|||::.|..:...|.||:|:||:.....:|..|..:...|||.   .||.
  Rat    86 VKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK---DHVC 147

  Fly   129 HYATEG---AYNVMVMDLLGPTLEDLLNLCSR-SFSMKTTLMLADQILARVELLHRRCFIHRDIK 189
            .:...|   .:|.:||.|.|..|.||....|| :|::.|||.|..|||..:|.:|...|:|||||
  Rat   148 RFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHSVGFLHRDIK 212

  Fly   190 PDNFLMGLNRHQT---QVYMIDFGLAKKFYS----LRTQKHI-GYTENRDLVGTARYASVRAH-Y 245
            |.||.||  |..:   :.:|:|||||::|.:    :|..:.: |:.      ||.||||:.|| .
  Rat   213 PSNFAMG--RFPSTCRKCFMLDFGLARQFTNSCGDVRPPRAVAGFR------GTVRYASINAHRN 269

  Fly   246 AEQSRRDDLESVGYLLLYFQRGRLPWQGIRAQSQAQKYEKIAEYKANIPLQQLCSGLPVEFFMYL 310
            .|..|.|||.|:.|:|:.|..|:|||:.|:.:      |::...|.....:.:...||.||..:|
  Rat   270 REMGRHDDLWSLFYMLVEFVVGQLPWRKIKDK------EQVGSIKERYDHRLMLKHLPPEFSTFL 328

  Fly   311 KYCRKLHFAEKPDYVYLQQLFKVLFRNQYKVCDFL----FDWV---------------------- 349
            .:...|.:..||||    ||...:|.|..|....:    |||.
  Rat   329 DHISSLDYFTKPDY----QLLTSVFDNSIKTFGVIESDPFDWEKSGTDGSLTTTTTSATPQLHTR 389

  Fly   350 -----------------VLKRESPEQQSQQKGRERDRGGKRNVVVQK-------ERHRNKD--RD 388
                             :|:..:.|....::..:.:.|....|...|       .|.:.||  .:
  Rat   390 LTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPAGVSPDKLPGSLGHPRPQEKDVWEE 454

  Fly   389 SDTQRCRIKNGGDLLEIEENESTTGEDPNEDKPQKKHGK------ACSCSYHLQ-KKRLQDRDRR 446
            .|..:.:||.|......||..|              ||:      |.|....:: :..:...||.
  Rat   455 MDINKNKIKLGICKAATEEENS--------------HGQVNGILNAPSLGSPIRVRSEITQPDRD 505

  Fly   447 APLMTE-RRILSGEQEQELELE 467
            .||:.: |.|.|.|.|:.|.||
  Rat   506 VPLVRKLRSIHSFELEKRLTLE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12147	NP_649536.1	STKc_CK1	67..331	CDD:270918	98/276 (36%)
CG12147	NP_649536.1	SPS1	67..>306	CDD:223589	89/251 (35%)
Ttbk2	XP_006234899.2	STKc_TTBK2	89..350	CDD:271031	99/281 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810