DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12147 and R10D12.10

DIOPT Version :9

Sequence 1:	NP_649536.1	Gene:	CG12147 / 40651	FlyBaseID:	FBgn0037325	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_506465.2	Gene:	R10D12.10 / 187766	WormBaseID:	WBGene00011191	Length:	497	Species:	Caenorhabditis elegans

Alignment Length:	505	Identity:	111/505 - (21%)
Similarity:	206/505 - (40%)	Gaps:	101/505 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RQDRRFSEEKQSLPEIIVAGKYRLLKRIGNGSFGELFQAEGLKYHEKVAIKLE--SSTVKHPLLP 109
            :.|...|..|...|::   |.:..:..|..|....:.:....:...:.|:|:|  |...|...:.
Worm     9 KSDNNGSVSKAHEPKL---GSWFSIGEIAKGDLSTVSRVIDSEGKIEAAMKVEKLSKDSKKRSIE 70

  Fly   110 REARIYGILQGGLGIPHVKHYATE---GAYNVMVMDLLGPTLEDLLNLCSRSFSMKTTLMLADQI 171
            ::     :|:.....||..|...:   |.|...||.|.||||..:.::....||..|.|.|:.:.
Worm    71 KD-----VLEALRDSPHSAHIIEQLLIGDYRFTVMTLSGPTLGIIKHIMDNKFSDSTILRLSMRT 130

  Fly   172 LARVELLHRRCFIHRDIKPDNFLMGLNRHQTQVYMIDFGLAKKF-------YSLRTQKHIGYTEN 229
            |..::.||...|||||::|.|..:...:....:.::|||.|::|       :.||..:     :.
Worm   131 LMAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPR-----DK 190

  Fly   230 RDLVGTARYASVRAH-YAEQSRRDDLESVGYLLLYFQRGRLPW--QGIRAQSQAQKYEKIAEYKA 291
            ....|:.:|.|.|.| :.||.|.|||.|..|:.:.. |..|||  ...|.:....|.|.:.:..|
Worm   191 APFRGSDQYCSPRMHNHEEQGRVDDLWSWLYVFVEL-RAFLPWTDSTSRFKYGPLKRELLDDLLA 254

  Fly   292 NIP-LQQLCS----------------GLPVEFF------MYLKYCRKLHF---AEKPDY------ 324
            :.| :...|.                |...|..      |.:|:...:.|   |:||:|
Worm   255 SDPFITTFCPIVTLLREGKYADRPDYGKIYEILAAKMTSMGVKWTDPMDFDLQADKPNYFSKSPS 319

  Fly   325 ---VYLQQLFKVLFRN-------QYKV---CDFLFDWVVLKRESPEQQSQQKGRERDRGGKRNVV 376
               |...:.....|..       ||.:   ..|..:..|:|:...:::.::|.:|:::  :::..
Worm   320 NEEVMTDEQISAAFHEQIVPGGLQYVLPANVPFYAEEKVVKKNKEKEREKEKDKEKEK--EKDKE 382

  Fly   377 VQKERHRNKDRDSDTQRCRIKNGGDLLE-------IEENESTTGEDPNED-----KPQK------ 423
            .:||:.:.|::|.:.:|.:.|:...:.|       :|:....|.|.|:.:     ||:|
Worm   383 KEKEKEKEKEKDKEKEREKRKSKEKIKEKEKKMGSLEKTTERTSEAPSTNALPKAKPKKIRTLPP 447

  Fly   424 --KHGK---ACSCSYHLQKKRLQDRDRRAPLMTERRILS--GEQEQELEL 466
              ||.|   ..|.|:......::....:.|...:::.:|  |..:|:.::
Worm   448 KQKHTKTSSTSSVSHQTPPSPIKKPSPKLPAQVKKKTVSTGGGSKQKAKI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12147	NP_649536.1	STKc_CK1	67..331	CDD:270918	75/313 (24%)
CG12147	NP_649536.1	SPS1	67..>306	CDD:223589	66/270 (24%)
R10D12.10	NP_506465.2	PKc_like	27..287	CDD:389743	67/270 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810