DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12147 and H05L14.1

DIOPT Version :9

Sequence 1:	NP_649536.1	Gene:	CG12147 / 40651	FlyBaseID:	FBgn0037325	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_492198.1	Gene:	H05L14.1 / 172575	WormBaseID:	WBGene00010366	Length:	794	Species:	Caenorhabditis elegans

Alignment Length:	362	Identity:	92/362 - (25%)
Similarity:	171/362 - (47%)	Gaps:	72/362 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EIIVAGKY--RLLKRIGNGSFGELF-----QAEGLKYHEKVAIKLESSTVKHPLLPREARIYGIL 118
            ::|..|:|  ::::.:|:|.||:::     :|:|.| ....|:|.||...|..:|..:..:..::
Worm   452 DVITNGQYAWKVVRLLGSGGFGDVYKVFDDKAKGPK-KTHYALKTESEGGKKAMLRLKVEMQVMI 515

  Fly   119 ---------QGGLGIPHVKHY--------ATEGAYNVMVMDLLGPTLEDLLNLCSRSFSM----- 161
                     :|.:.    :|:        :.|.....:||.|:||:|:|    |.|.|.:
Worm   516 TISDARKKSKGDVN----RHFVDFIDRGKSEELKCKYIVMSLVGPSLDD----CRRKFGVNLSNT 572

  Fly   162 KTTLMLADQILARVELLHRRCFIHRDIKPDNFLMGLNRHQTQVYMIDFGLAKKFYSLRTQKHIGY 226
            .|..::|.|.|..:..||...::||||||.||.:|:...::.|:|:|||:.:.:...:|::|...
Worm   573 STPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGVGAKESTVFMLDFGIGRSYLDPKTKQHRAP 637

  Fly   227 TENRDLVGTARYASVRAHYAE--QSRRDDLESVGYLL--LYFQRGRLPWQGIRAQSQAQKYEKI- 286
            .:....:||.|||| ||...|  |.|:||||...|::  ::..:..:.|:..|.:.:.::.:::
Worm   638 RKKVKFLGTLRYAS-RACMLEVDQGRKDDLECWIYMVFDIFDPKNGVSWKKQRDRVKIREAKQLF 701

  Fly   287 ----AEYKANIPLQQLCSGLPVEFFMYLKYCRKLHFAEKPDYVYLQQLFKVLFRNQ----YKVCD 343
                |:|          ...|:.....:.|...|.|...|:|.   .|.|.|:.:.    |.: .
Worm   702 FDGKAQY----------DYAPISLRPIIIYINSLQFQTTPEYA---NLVKTLYTSSSASGYPI-H 752

  Fly   344 FLFD--WV-VLKRESP---EQQSQQKGRERDRGGKRN 374
            .|.|  || .||:|:.   |:::.:.|......||::
Worm   753 SLDDGGWVGKLKKEAKSKMEKKTARFGDSSSESGKQS 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12147	NP_649536.1	STKc_CK1	67..331	CDD:270918	75/301 (25%)
CG12147	NP_649536.1	SPS1	67..>306	CDD:223589	70/276 (25%)
H05L14.1	NP_492198.1	PKc_like	137..385	CDD:304357
		SPS1	194..>369	CDD:223589
		PKc_like	461..736	CDD:304357	74/297 (25%)
		SPS1	461..>651	CDD:223589	52/198 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810