DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12147 and Ttbk1

DIOPT Version :9

Sequence 1:	NP_649536.1	Gene:	CG12147 / 40651	FlyBaseID:	FBgn0037325	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001156336.1	Gene:	Ttbk1 / 106763	MGIID:	2147036	Length:	1308	Species:	Mus musculus

Alignment Length:	439	Identity:	136/439 - (30%)
Similarity:	198/439 - (45%)	Gaps:	99/439 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KDQRQDRRFSEEKQSLP-EIIVAGKYRLLKRIGNGSFGELFQAEGLKYHEKVAIKLESSTVKHPL 107
            ||:.......|:...|| ..:|..::::||:||.|.|||:::|..|...|.||:|:||:.....:
Mouse     9 KDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV 73

  Fly   108 LPREARIYGILQGGLGIPHVKHYATEG---AYNVMVMDLLGPTLEDLLNLCSR-SFSMKTTLMLA 168
            |..|..:...|||.   .||..:...|   .:|.:||.|.|..|.||.....| :|::.|||.|.
Mouse    74 LKMEVAVLKKLQGK---DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLG 135

  Fly   169 DQILARVELLHRRCFIHRDIKPDNFLMG-LNRHQTQVYMIDFGLAKKFYS----LRTQKHI-GYT 227
            .|||..:|.:|...|:||||||.||.|| |.....:.||:|||||:::.:    :|..::: |:.
Mouse   136 KQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR 200

  Fly   228 ENRDLVGTARYASVRAH-YAEQSRRDDLESVGYLLLYFQRGRLPWQGIRAQSQA----QKYEKIA 287
                  ||.|||||.|| ..|..|.|||.|:.|:|:.|..|:|||:.|:.:.|.    :|||.
Mouse   201 ------GTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEH-- 257

  Fly   288 EYKANIPLQQLCSGLPVEFFMYLKYCRKLHFAEKPDYVYLQQLFKVLFRNQYK----VCDFLFDW 348
                    :.|...:|.||.::|.:...|.:..||||    ||...:|.|..|    ..:..|||
Mouse   258 --------RMLLKHMPSEFHLFLDHIASLDYFTKPDY----QLIMSVFENSMKERGIAENEAFDW 310

  Fly   349 ------VVLKRES---PEQQSQQKGRERDRGGKRNVVVQKERHRNKDRDSDTQRCRIKNGGDLLE 404
                  .:|...:   |:|.::|...   ..|..||....                    ||||
Mouse   311 EKAGTDALLSTSTSTPPQQNTRQTAA---MFGVVNVTPVP--------------------GDLL- 351

  Fly   405 IEENESTTGEDPNEDKPQKKHGKACSCSYHLQKKRLQDRDRRAPLMTER 453
             .||        .||..|.:|              |.|::...|::..|
Mouse   352 -REN--------TEDVLQGEH--------------LSDQENAPPILPGR 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12147	NP_649536.1	STKc_CK1	67..331	CDD:270918	102/278 (37%)
CG12147	NP_649536.1	SPS1	67..>306	CDD:223589	93/253 (37%)
Ttbk1	NP_001156336.1	STKc_TTBK1	33..294	CDD:271032	103/283 (36%)
		PHA03307	324..>683	CDD:223039	20/101 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..397		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..448
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..671
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..899
		PHA03307	963..>1305	CDD:223039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	985..1085
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810