DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2663 and CLVS1

DIOPT Version :9

Sequence 1:	NP_649535.2	Gene:	CG2663 / 40649	FlyBaseID:	FBgn0037323	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_775790.1	Gene:	CLVS1 / 157807	HGNCID:	23139	Length:	354	Species:	Homo sapiens

Alignment Length:	249	Identity:	66/249 - (26%)
Similarity:	123/249 - (49%)	Gaps:	12/249 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TPDQRVSIREELREPEDPADIERDIKLIREWLETQPHLP-KDMDDMRLTTFLRGCKFSLEKVKKK 70
            :|:.....|.||.  |:|..:.:||:.:|:.:.|:|.:. ...||..:..|||..||......:.
Human    31 SPETIEKARLELN--ENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRL 93

  Fly    71 LDMYYTMRNAVPEFFSNRDINREELNIVLDYVHCPTLPGITPN----GRRITFIRGIDCDFQPHH 131
            |..|:..|....:.|.|...:...:...|    ....||:..|    ||:|..:...:.|...:.
Human    94 LAQYFQYRQLNLDMFKNFKADDPGIKRAL----IDGFPGVLENRDHYGRKILLLFAANWDQSRNS 154

  Fly   132 ILDAMKVALMIGDVRLAEESVGIAGDIFILDASVASAAHFAKFSPTVVKKFLIAVQEAYPVKVKE 196
            ..|.::..|:..:|.:.:..:.|.|.|.|:|.|..|....:|.:|:::|..:..:|:::|.:...
Human   155 FTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGG 219

  Fly   197 VHVINISPLVDTIFNFVKPFVKEKIRSRITFH-NDVESLYKVVPRDLLPNEYGG 249
            ||.:|....:..::..:|||:|:|.|.||..| |::.||::::..:.||:|:||
Human   220 VHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGG 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2663	NP_649535.2	CRAL_TRIO_N	28..74	CDD:215024	13/46 (28%)
CG2663	NP_649535.2	SEC14	95..250	CDD:238099	43/160 (27%)
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	13/45 (29%)
		CRAL_TRIO	125..274	CDD:306996	42/149 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920