Protein Alignment amfra and HRD1

DIOPT Version :9

• Sequence 1: NP_998328.2
• Gene: amfra / 406442
• ZFINID: ZDB-GENE-040426-2190
• Length: 620
• Species: Danio rerio
• Sequence 2: NP_014630.1
• Gene: HRD1 / 854149
• SGDID: S000005373
• Length: 551
• Species: Saccharomyces cerevisiae
• Alignment Length: 628
• Identity: 113/628 - (17%)
• Similarity: 226/628 - (35%)
• Gaps: 220/628 - (35%)

Zfish    14 LQTYTALSALLLAGTVLSAYSTVRDS----EFSSALSEGPQNEELKLENLGNVATGVLLHLITDS 74
            |..:..::.||   |....||..:.|    :.:..|:||                   .:|:..|
Yeast    10 LAIFVVVTYLL---TFYCVYSATKTSVSFLQVTLKLNEG-------------------FNLMVLS 52

Zfish    75 LFVWVMVNTACCILMLIGKVIQCIVFGPLRVSEKQHLKDK---------FWNFIFYKFIF----I 126
            :|  :::|:.     |:.:::..::||.||:.|.:|:.::         |.:.:|::..|    .
Yeast    53 IF--ILLNST-----LLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAF 110

Zfish   127 FGVLNVQRVEEVVLWCLWFSMLIFLHLMVQLCKDRFEYL--SFSPTTPM--------SSHVRVLA 181
            ||:|                 |::|.:...:.|||.|.|  |.:.:|.|        |.::.:||
Yeast   111 FGLL-----------------LLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLA 158

Zfish   182 LL-VSVLSCCGGLAVLCALAGHIHGMHTVAFMAAECLLVTVRTGHVIIRYSIHLWDL-------- 237
            :: ..:::.|.. ::.......|...........|..::.:...::.::..::.|:.
Yeast   159 VVDYQIITRCIS-SIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLS 222

Zfish   238 ---NH--------EGTWENKSS-----------------------YIY------YTDFIMELAIL 262
               ||        |.|.|:..|                       ::|      :|.|:.....|
Yeast   223 NENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHL 287

Zfish   263 SLDLMHHIHMLLFGN-IWLSMASLVIFMQLRHLFHEVQRRIRRHKNYLRVIDNMESRFAVATPEE 326
            |:.:...:.|:|..: :|   ..|.::.....|:     :|.|:...|      :......|.|:
Yeast   288 SMLIPFRMPMMLLKDVVW---DILALYQSGTSLW-----KIWRNNKQL------DDTLVTVTVEQ 338

Zfish   327 L--AANNDD-CAICWDSMTTA-------------RKLPCGHLFHNSCLRSWLEQDTSCPTCRMSL 375
            |  :||:|: |.||.|.:..:             ::|||||:.|.|||::|:|:..:||.||:.:
Yeast   339 LQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPV 403

Zfish   376 NIHEGRREREEGQREPLEDNMAAAGAADARAHINQHNHFFHFDGSRIASWLPSFSVEVMHT--TN 438
                                                   |...|:.:.:...|.|.....|  |:
Yeast   404 ---------------------------------------FDEKGNVVQTTFTSNSDITTQTTVTD 429

Zfish   439 ILGIAQANNSQLNGMAHQIQEMFPQVPYHLILQDLQLTRSVEVTTDNILEGRIQVPFPTQSTDRT 503
            ..|||    :...|.|:::.    .:|......|:::..:..:.|..:.......|.||..|
Yeast   430 STGIA----TDQQGFANEVD----LLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYT--- 483

Zfish   504 PIQMNAASEDGAGASSGSEVAAPEAEDFEVRGSRFSKSADERQ 546
             ..::...::..|:|.       .|.:|.:..|      ||::
Yeast   484 -FPLHKTGDNSVGSSR-------SAYEFLITNS------DEKE 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amfra	NP_998328.2	zf-rbx1	79..>375	CDD:331150	75/384 (20%)
		RING-H2_AMFR	332..375	CDD:319369	20/56 (36%)
		RING-H2 finger (C3H2C3-type)	334..371	CDD:319369	17/49 (35%)
		CUE_AMFR	451..491	CDD:270604	5/39 (13%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	113/628 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I2991
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810