DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amfra and amfr

DIOPT Version :9

Sequence 1:	NP_998328.2	Gene:	amfra / 406442	ZFINID:	ZDB-GENE-040426-2190	Length:	620	Species:	Danio rerio
Sequence 2:	NP_001017083.1	Gene:	amfr / 549837	XenbaseID:	XB-GENE-923086	Length:	635	Species:	Xenopus tropicalis

Alignment Length:	645	Identity:	432/645 - (66%)
Similarity:	502/645 - (77%)	Gaps:	39/645 - (6%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MPLLFLERFPWPSLQTYTALSALLLAGTVLSAYSTVRDSEFSSALSEGPQ-NEELKLENLGNVAT 64
            ||||||||||||||:|||.||.|||..::||||.::.......::.||.: ..:|..|.:..|.
Frog     1 MPLLFLERFPWPSLRTYTGLSGLLLGLSLLSAYRSLSGEAAERSMLEGEEAGAQLPPEPVDLVE- 64

Zfish    65 GVLLHLITDSLFVWVMVNTACCILMLIGKVIQCIVFGPLRVSEKQHLKDKFWNFIFYKFIFIFGV 129
             :..:|::|||.|||:|||.||:||||.|:||.:|||||||.|:|||||||||||||||||||||
Frog    65 -LFRYLVSDSLGVWVLVNTVCCLLMLIAKLIQHVVFGPLRVGERQHLKDKFWNFIFYKFIFIFGV 128

Zfish   130 LNVQRVEEVVLWCLWFSMLIFLHLMVQLCKDRFEYLSFSPTTPMSSHVRVLALL-VSVLSCCGGL 193
            ||||.|||||||.|||:.|:|||||||||||||||||||||||||.|:|||.|| :.:|:|| ||
Frog   129 LNVQTVEEVVLWFLWFAGLLFLHLMVQLCKDRFEYLSFSPTTPMSCHMRVLVLLNIMLLACC-GL 192

Zfish   194 AVLCALAGHIHGMHTVAFMAAECLLVTVRTGHVIIRYSIHLWDLNHEGTWENKSSYIYYTDFIME 258
            |||||:||:.|||||:|||||||:|||.||.||::||.|||||||||||||.|.:|:|||||:||
Frog   193 AVLCAIAGYTHGMHTLAFMAAECMLVTTRTTHVVLRYVIHLWDLNHEGTWEGKGTYVYYTDFVME 257

Zfish   259 LAILSLDLMHHIHMLLFGNIWLSMASLVIFMQLRHLFHEVQRRIRRHKNYLRVIDNMESRFAVAT 323
            |:.||:|||||||||||||||||||||||||||||||||.|||||||||||||:.|||:.|||||
Frog   258 LSHLSIDLMHHIHMLLFGNIWLSMASLVIFMQLRHLFHEFQRRIRRHKNYLRVVGNMEAHFAVAT 322

Zfish   324 PEELAANNDDCAICWDSMTTARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIHEGRREREEGQ 388
            ||||.||:||||||||||.:|||||||||||||||||||||||||||||||||:.:|.|.|.|.|
Frog   323 PEELEANSDDCAICWDSMQSARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNMADGTRTRVEQQ 387

Zfish   389 REPLEDNMAAAGAADARAHINQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIAQANNSQLNGM 453
            ||..:.|.......:.|..:|.|||||||||||.|||||||||||||||||||:|||:|||||.|
Frog   388 RENQDQNAVPLAVTEGRPRLNHHNHFFHFDGSRFASWLPSFSVEVMHTTNILGLAQASNSQLNAM 452

Zfish   454 AHQIQEMFPQVPYHLILQDLQLTRSVEVTTDNILEGRIQVPFPTQSTD----RTPIQMNAASEDG 514
            |.|:.:|||||||||:|||||||||||:|||||||||||||||||..|    .|.....:|.|:.
Frog   453 ARQVLDMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQHQDDVRSATETSEVSAQEES 517

Zfish   515 AGAS-------------------SGSEVAAPEAEDFEVRGSRFSKSADERQRMLMQRKEELLLRA 560
            :.|:                   |..|....:.|:||.|||||||||:||||||:||||:::..|
Frog   518 STATQTERVNLDLSPGLEEYEDFSVIEAQVSDVEEFEARGSRFSKSAEERQRMLVQRKEDMVQLA 582

Zfish   561 RRRYLHKKPEDG--DAYSVLGADNDDSVPSIEDEDSDSVTLRRRRLAAAAERRI-LRQEP 617
            |||:|::..|:.  |..|..|:..|.|        |||.|:|||.||||||||| ::|.|
Frog   583 RRRFLNRTSEEDNPDCSSERGSHTDSS--------SDSTTVRRRMLAAAAERRIQMQQSP 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amfra	NP_998328.2	zf-rbx1	79..>375	CDD:331150	246/296 (83%)
		RING-H2_AMFR	332..375	CDD:319369	40/42 (95%)
		RING-H2 finger (C3H2C3-type)	334..371	CDD:319369	34/36 (94%)
		CUE_AMFR	451..491	CDD:270604	32/39 (82%)
amfr	NP_001017083.1	HRD1	75..>374	CDD:227568	248/299 (83%)
		RING-H2_AMFR	331..374	CDD:319369	40/42 (95%)
		RING-H2 finger (C3H2C3-type)	333..370	CDD:319369	34/36 (94%)
		CUE_AMFR	450..490	CDD:270604	32/39 (82%)
		G2BR	564..589	CDD:375868	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	497	1.000	Domainoid score	I2850
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H888
Inparanoid	1	1.050	850	1.000	Inparanoid score	I3079
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D149264at7742
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	1	1.000	-	-		oto78954
Panther	1	1.100	-	-	LDO	PTHR15067
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8523
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190