DRSC/TRiP Functional Genomics Resources

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Protein Alignment amfra and AMFR

DIOPT Version :9

Sequence 1:NP_998328.2 Gene:amfra / 406442 ZFINID:ZDB-GENE-040426-2190 Length:620 Species:Danio rerio
Sequence 2:NP_001310441.1 Gene:AMFR / 267 HGNCID:463 Length:675 Species:Homo sapiens


Alignment Length:689 Identity:454/689 - (65%)
Similarity:517/689 - (75%) Gaps:85/689 - (12%)


- Green bases have known domain annotations that are detailed below.


Zfish     1 MPLLFLERFPWPSLQTYTALSALLLAGTVLSAYSTVRDSEFSSALSEGPQNEELKLENL------ 59
            ||||||||||||||:|||.||.|.|.||::|||..:...|      .||...:....:|      
Human     1 MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPE------AGPGEPDQLTASLQPEPPA 59

Zfish    60 -------GNVATGVLLHLITDSLFVWVMVNTACCILMLIGKVIQCIVFGPLRVSEKQHLKDKFWN 117
                   |..|..|..:|::|||||||:||||||:|||:.|:|||||||||||||:|||||||||
Human    60 PARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWN 124

Zfish   118 FIFYKFIFIFGVLNVQRVEEVVLWCLWFSMLIFLHLMVQLCKDRFEYLSFSPTTPMSSHVRVLAL 182
            ||||||||||||||||.|||||:|||||:.|:|||||||||||||||||||||||||||.|||:|
Human   125 FIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSL 189

Zfish   183 LVSVLSCCGGLAVLCALAGHIHGMHTVAFMAAECLLVTVRTGHVIIRYSIHLWDLNHEGTWENKS 247
            ||::|..|.|||.:|::.|:.|||||:||||||.|||||||.|||:||.|||||||||||||.|.
Human   190 LVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKG 254

Zfish   248 SYIYYTDFIMELAILSLDLMHHIHMLLFGNIWLSMASLVIFMQLRHLFHEVQRRIRRHKNYLRVI 312
            :|:|||||:|||.:|||||||||||||||||||||||||||||||:||||||||||||||||||:
Human   255 TYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVV 319

Zfish   313 DNMESRFAVATPEELAANNDDCAICWDSMTTARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNI 377
            .|||:|||||||||||.||||||||||||..||||||||||||||||||||||||||||||||||
Human   320 GNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNI 384

Zfish   378 HEGRREREEGQREPLEDNMAAAGAADARAHINQHNHFFHFDG----------------------- 419
            .:..|.|||.|.|.|::|:....||:.|..:|||||||||||                       
Human   385 ADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGDDSSMRVTAPEDVPVGQEVEVVD 449

Zfish   420 ---------SRIASWLPSFSVEVMHTTNILGIAQANNSQLNGMAHQIQEMFPQVPYHLILQDLQL 475
                     |||||||||||||||||||||||.||:|||||.||||||||||||||||:||||||
Human   450 SDTDAPDLWSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQL 514

Zfish   476 TRSVEVTTDNILEGRIQVPFPTQSTD------RTPIQMNAASEDGAGASSGS------------- 521
            |||||:|||||||||||||||||.:|      .:|::..::.::....|:.:             
Human   515 TRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEE 579

Zfish   522 -------EVAAPEAEDFEVRGSRFSKSADERQRMLMQRKEELLLRARRRYLHKKPEDGDAYSVLG 579
                   ||...|.||||.||||||||||||||||:|||:|||.:||:|:|:|..|| ||.|   
Human   580 TLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSED-DAAS--- 640

Zfish   580 ADNDDSVPSIEDEDSDSVTLRRRRLAAAAERRILRQEPS 618
               :..:|| |...||.||||||.||||||||:.:|:.|
Human   641 ---ESFLPS-EGASSDPVTLRRRMLAAAAERRLQKQQTS 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
amfraNP_998328.2 zf-rbx1 79..>375 CDD:331150 251/295 (85%)
RING-H2_AMFR 332..375 CDD:319369 40/42 (95%)
RING-H2 finger (C3H2C3-type) 334..371 CDD:319369 34/36 (94%)
CUE_AMFR 451..491 CDD:270604 36/39 (92%)
AMFRNP_001310441.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C194343496
Domainoid 1 1.000 516 1.000 Domainoid score I2541
eggNOG 1 0.900 - - E1_COG5243
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H888
Inparanoid 1 1.050 899 1.000 Inparanoid score I2838
NCBI 1 1.000 - -
OMA 1 1.010 - - QHG55068
OrthoDB 1 1.010 - - D149264at7742
OrthoFinder 1 1.000 - - FOG0006872
OrthoInspector 1 1.000 - - oto45703
orthoMCL 1 0.900 - - OOG6_105132
Panther 1 1.100 - - LDO PTHR15067
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3836
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 1 1.500 - -
1818.270

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