DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amfra and hrdl-1

DIOPT Version :9

Sequence 1:	NP_998328.2	Gene:	amfra / 406442	ZFINID:	ZDB-GENE-040426-2190	Length:	620	Species:	Danio rerio
Sequence 2:	NP_492602.2	Gene:	hrdl-1 / 172833	WormBaseID:	WBGene00009164	Length:	579	Species:	Caenorhabditis elegans

Alignment Length:	603	Identity:	151/603 - (25%)
Similarity:	266/603 - (44%)	Gaps:	103/603 - (17%)

- Green bases have known domain annotations that are detailed below.

Zfish     6 LERFPWPSLQTYTALSALLLAGTVLSAYSTVRDS-EFSSALSEGPQNEE-------LKLENL-GN 61
            |.|..:||:.:|.|||.|:.....::.::|.|.. |....:.|..:|..       |.:|.| |:
Worm    22 LSRSSFPSVDSYLALSVLVAIVASVTVFTTFRSQPELQKLIEEELRNNTRLSSAYGLNIEALSGH 86

Zfish    62 VATGVLLHLITDSLFVWVMVNTACCILMLIGKVIQCIVFGPLRVSEKQHLKDKFWNFIFYKFIFI 126
            ....:..::::|:..:||.:|:...||.:..::|..:.|..|...|:...:..|:.::....:::
Worm    87 TFFQIAHYILSDTTLIWVAINSYFAILAVCTRLIIKLTFKELARQEENVARQAFFCYVLLTIVYL 151

Zfish   127 FGVLNVQRVEEVVLWCLWFSMLIFL-HLMVQLCKDRFEYLSFSPTTPMSSH-VRVLALLVSVLSC 189
            ..|:..|:...|:.|.:|..:..|| ||....|: |.:::  ||:....|. :..|:|.:..:|.
Worm   152 SVVIGPQKGHRVMPWMIWGGICAFLSHLQFITCQ-RLKHI--SPSCDRGSQKISFLSLFLFFVSI 213

Zfish   190 CGGLAVLCALAGHIHGMHTVAFMAAECLLVTVRTGHVIIR-------YSIHLWDLNHEGTWENKS 247
              .:..|.:...|.........:..:|||...|:.:::.|       :|.:...:.|...|..
Worm   214 --AMTFLISRFQHHLTWQPAVLLYFDCLLAVFRSTYILFRCISSSRVFSFNPDSVRHFNYWLE-- 274

Zfish   248 SYIYYTDFIMELAILSLDLMHHIHMLLFGNI-----WLSMASLVIFMQLRHLFHEVQRRIRRHKN 307
               ..|:|:.||          |.||.|..:     .|::.|:.....::..::.:..::.||:|
Worm   275 ---LITNFVCEL----------IQMLSFAQLLAFSPGLNLTSIFFLYHMKLTYNCMTEQLSRHRN 326

Zfish   308 YLRVIDNMESRFAVATPEELAANNDD-CAICWDSMTTARKLPCGHLFHNSCLRSWLEQDTSCPTC 371
            :.::.:::|..:    |....||.|| |.:||:.:.|:|:|||.|.||:.||..||.||:|||||
Worm   327 HKKIFEHIERSY----PSVKCANGDDRCVVCWELLGTSRRLPCSHQFHDWCLMWWLAQDSSCPTC 387

Zfish   372 RMSLNIHEG--RREREEGQREPLEDNMAAAGAADARAHINQHNHFFHFDGSRIASWLPSFSVEVM 434
            |.::...:.  |:..|.|....|..|..:.|             |.||         |:|::||.
Worm   388 RCTIPSPQDQIRQPPEVGNSTRLRFNGGSFG-------------FVHF---------PAFTLEVA 430

Zfish   435 HTTN-ILG-IAQANNSQLNGMAHQIQEMFPQVPYHLILQDLQLTRSVEVTTDNILEGRIQVPFPT 497
            .... ..| .|:....||..|..|::|||||:...:|:.||:.:.|.:.|.:||||||
Worm   431 ANFGPFFGRAAEPTEEQLQTMLEQVREMFPQMSVDIIMTDLRQSGSAQSTIENILEGR------- 488

Zfish   498 QSTDRTPIQMNAA------SEDGAGASSGSEVAAPEAEDF--EVRGSR-------FSKSADERQR 547
                   |.|||:      .:|.....|.:|:...|..:.  |....|       .|.|.||...
Worm   489 -------IGMNASFMPGGVLDDELSDESENEIEYEEPAEIVQEPDNGRQRTWTKLSSSSGDEDLS 546

Zfish   548 MLMQRKEELLLRARRRYL 565
            ....::.:::...||:||
Worm   547 YYEIQRAKMIETYRRKYL 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amfra	NP_998328.2	zf-rbx1	79..>375	CDD:331150	78/310 (25%)
		RING-H2_AMFR	332..375	CDD:319369	25/43 (58%)
		RING-H2 finger (C3H2C3-type)	334..371	CDD:319369	20/36 (56%)
		CUE_AMFR	451..491	CDD:270604	17/39 (44%)
hrdl-1	NP_492602.2	HRD1	<200..>407	CDD:227568	58/227 (26%)
		zf-RING_2	348..388	CDD:290367	22/39 (56%)
		CUE_AMFR	449..489	CDD:270604	18/53 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161032777
Domainoid	1	1.000	65	1.000	Domainoid score	I7252
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H888
Inparanoid	1	1.050	170	1.000	Inparanoid score	I3166
OMA	1	1.010	-	-		QHG55068
OrthoDB	1	1.010	-	-		D271732at33208
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	1	1.000	-	-		otm13239
orthoMCL	1	0.900	-	-		OOG6_105132
Panther	1	1.100	-	-	LDO	PTHR15067
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8523
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800