DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14667 and E4F1

DIOPT Version :9

Sequence 1:	NP_001014607.1	Gene:	CG14667 / 40643	FlyBaseID:	FBgn0037317	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	XP_005255212.1	Gene:	E4F1 / 1877	HGNCID:	3121	Length:	837	Species:	Homo sapiens

Alignment Length:	256	Identity:	70/256 - (27%)
Similarity:	112/256 - (43%)	Gaps:	54/256 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 VHVE----------LSSEPLDEQLIDADQLETHYDDDQYVCYQGTKEE--HQDL----------- 132
            |||:          |:.||...|.:....             :|::|.  ||.:
Human   388 VHVQMQELSLGMKALAPEPPVSQELPCSS-------------EGSRENLLHQAMQNSGIVLERAA 439

  Fly   133 -EEIELDDDPSAAVIAAAEAAAEAAQQ------EDLQEQ-EMERAAKRRSNFFICDECGTLFHDA 189
             ||..|:..|:|.  ::.:..|.||.|      :.|:.| ..|.:|..|::  .|.:|...|..|
Human   440 GEEGALEPAPAAG--SSPQPLAVAAPQLPVLEVQPLETQVASEASAVPRTH--PCPQCSETFPTA 500

  Fly   190 FLYTEHLNGHQNRRDMNQFFPCPECPQTFNKKALLKQHRTQVHLINRRFQCTICHEAFASLGAKL 254
            .....|..||...|.    |.|.:|.:.|.|..|||:|: :||:..|||:|..|.:.:.::....
Human   501 ATLEAHKRGHTGPRP----FACAQCGKAFPKAYLLKKHQ-EVHVRERRFRCGDCGKLYKTIAHVR 560

  Fly   255 RHDKAHKNERPYPCLECGMIFSSVSELQNHFSTHSKQIRKFRCEPCNMDFITRRGLVAHTK 315
            .|.:.|.:||||||.:||..:.:.:..|.||.||.:: :...|:.|:..|..:..||.|.:
Human   561 GHRRVHSDERPYPCPKCGKRYKTKNAQQVHFRTHLEE-KPHVCQFCSRGFREKGSLVRHVR 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14667	NP_001014607.1	zf-AD	6..80	CDD:214871
		C2H2 Zn finger	179..199	CDD:275368	5/19 (26%)
		C2H2 Zn finger	211..232	CDD:275368	8/20 (40%)
		C2H2 Zn finger	240..260	CDD:275368	3/19 (16%)
		zf-C2H2_8	243..313	CDD:292531	21/69 (30%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		C2H2 Zn finger	297..316	CDD:275368	6/19 (32%)
E4F1	XP_005255212.1	COG5048	236..648	CDD:227381	70/256 (27%)
		C2H2 Zn finger	247..267	CDD:275368
		zf-C2H2	273..295	CDD:278523
		C2H2 Zn finger	275..295	CDD:275368
		zf-H2C2_2	287..310	CDD:290200
		zf-C2H2	301..322	CDD:278523
		C2H2 Zn finger	303..321	CDD:275368
		C2H2 Zn finger	490..510	CDD:275368	5/19 (26%)
		DUF45	<506..585	CDD:302795	30/83 (36%)
		C2H2 Zn finger	518..538	CDD:275368	8/20 (40%)
		C2H2 Zn finger	546..566	CDD:275368	3/19 (16%)
		zf-H2C2_2	558..583	CDD:290200	10/24 (42%)
		C2H2 Zn finger	574..594	CDD:275368	6/19 (32%)
		zf-H2C2_2	588..609	CDD:290200	7/21 (33%)
		C2H2 Zn finger	602..622	CDD:275368	6/19 (32%)
		zf-H2C2_2	614..638	CDD:290200	3/7 (43%)
		C2H2 Zn finger	630..649	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5423
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950