DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14667 and ZNF560

DIOPT Version :9

Sequence 1:	NP_001014607.1	Gene:	CG14667 / 40643	FlyBaseID:	FBgn0037317	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_689689.2	Gene:	ZNF560 / 147741	HGNCID:	26484	Length:	790	Species:	Homo sapiens

Alignment Length:	442	Identity:	93/442 - (21%)
Similarity:	139/442 - (31%)	Gaps:	160/442 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RGKYLGQ----LKLITGVELTRNQGLPEIV-CERCFS--------ELDLATKFR---ERCIFSQK 76
            :|..|.|    ||.:.|::|.|||...|:. |::|..        :.:::|:.|   ..||...|
Human   185 KGPALWQDNFCLKTLNGIQLARNQNGEELYDCKQCEDVFCKHPCLKTNMSTQNRGNTSECIQYAK 249

  Fly    77 YLLDIIKKTSDQSTVHV----------------------------------------------EL 95
            .||.:..|||....|.|                                              ..
Human   250 DLLSLYNKTSTIRKVSVFSKHGKSFRLILNVQVQRKCTQDKSFEGTDYGKAFIYQSYLEAHRKTQ 314

  Fly    96 SSEPLDE----------QLIDADQLETHYDDDQYVCYQGTKE--------EHQD----------- 131
            |.|.|:|          ....|..:|||...:.|.|.:..|:        .|..
Human   315 SGEKLNEWKQCGEAFTHSTSHAVNVETHIIKNPYECKECGKDFRYPTHLNNHMQTHIGIKPYKCK 379

  Fly   132 ------------LEEI--ELDDDP------------SAAVIAAAEAAAEAAQ------------- 157
                        ||.:  ...:.|            ||.:|......|....
Human   380 HCGKTFTVPSGFLEHVRTHTGEKPYGCKECGKAFGTSAGLIEHIRCHAREKTFKCDHCGKAFISY 444

  Fly   158 ------------QEDLQEQEMERA--------AKRRSNF----FICDECGTLFHDAFLYTEHLNG 198
                        ::..:.:|..:|        ..||||.    |.||:||.:|........||..
Human   445 PSLFGHLRVHNGEKPYEHKEYGKAFGTSSGVIEDRRSNTGQKRFDCDQCGKVFVSFSSLFAHLRT 509

  Fly   199 HQNRRDMNQFFPCPECPQTFNKKALLKQHRTQVHLINRRFQCTICHEAFASLGAKLRHDKAHKNE 263
            |...:.    |.|.:|.:.|...|.|:.| .:.|...|.:||..|.:||.......:|.:.|..|
Human   510 HTGEKP----FKCYKCGKPFTSSACLRIH-MRTHTEERLYQCKKCGKAFTKCSYLTKHLRTHAGE 569

  Fly   264 RPYPCLECGMIFSSVSELQNHFSTHSKQIRKFRCEPCNMDFITRRGLVAHTK 315
            :||.|::||..|:..|.|..|...||.: :.:.|:.|...|..|..|..|.:
Human   570 KPYECMKCGKAFTERSYLTKHLRRHSGE-KPYECKKCGKAFTERSDLTKHLR 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14667	NP_001014607.1	zf-AD	6..80	CDD:214871	19/67 (28%)
		C2H2 Zn finger	179..199	CDD:275368	7/19 (37%)
		C2H2 Zn finger	211..232	CDD:275368	6/20 (30%)
		C2H2 Zn finger	240..260	CDD:275368	5/19 (26%)
		zf-C2H2_8	243..313	CDD:292531	22/69 (32%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	297..316	CDD:275368	6/19 (32%)
ZNF560	NP_689689.2	KRAB	13..69	CDD:214630
		KRAB	13..50	CDD:279668
		KRAB	110..161	CDD:214630
		KRAB	110..149	CDD:279668
		C2H2 Zn finger	294..314	CDD:275368	0/19 (0%)
		C2H2 Zn finger	323..342	CDD:275368	2/18 (11%)
		COG5048	344..754	CDD:227381	60/283 (21%)
		C2H2 Zn finger	350..370	CDD:275368	3/19 (16%)
		zf-H2C2_2	362..386	CDD:290200	1/23 (4%)
		C2H2 Zn finger	378..398	CDD:275368	2/19 (11%)
		C2H2 Zn finger	406..426	CDD:275368	3/19 (16%)
		C2H2 Zn finger	434..454	CDD:275368	0/19 (0%)
		C2H2 Zn finger	490..510	CDD:275368	7/19 (37%)
		zf-H2C2_2	502..527	CDD:290200	7/28 (25%)
		C2H2 Zn finger	518..538	CDD:275368	6/20 (30%)
		zf-H2C2_2	531..554	CDD:290200	8/23 (35%)
		C2H2 Zn finger	546..566	CDD:275368	5/19 (26%)
		zf-H2C2_2	558..582	CDD:290200	8/23 (35%)
		C2H2 Zn finger	574..594	CDD:275368	7/19 (37%)
		zf-H2C2_2	586..610	CDD:290200	6/24 (25%)
		zf-C2H2	600..622	CDD:278523	6/21 (29%)
		C2H2 Zn finger	602..622	CDD:275368	6/19 (32%)
		C2H2 Zn finger	630..650	CDD:275368
		C2H2 Zn finger	658..678	CDD:275368
		C2H2 Zn finger	714..734	CDD:275368
		zf-H2C2_2	726..751	CDD:290200
		C2H2 Zn finger	742..762	CDD:275368
		zf-H2C2_2	757..779	CDD:290200
		C2H2 Zn finger	770..790	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000