DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG14667 and CTCFL

DIOPT Version :9

Sequence 1:NP_001014607.1 Gene:CG14667 / 40643 FlyBaseID:FBgn0037317 Length:337 Species:Drosophila melanogaster
Sequence 2:NP_001255972.1 Gene:CTCFL / 140690 HGNCID:16234 Length:700 Species:Homo sapiens


Alignment Length:270 Identity:62/270 - (22%)
Similarity:101/270 - (37%) Gaps:45/270 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 IIKKTSDQSTVHVELSSEPLDEQLIDADQLETHYDDDQYVCYQGTKEEHQDLEEIELDDDPSAAV 145
            :||...:|.  ..:|.:|...|||...:.:......|:.|    ....:.::||.|  |.|:|  
Human   179 LIKLEEEQE--KNQLLAERTKEQLFFVETMSGDERSDEIV----LTVSNSNVEEQE--DQPTA-- 233

  Fly   146 IAAAEAAAEAAQQEDLQEQEMERAAK-------------RRSNF------------FICDECGTL 185
                 ..|:|.:.:..:.|...:.||             |.|:|            .:|..|...
Human   234 -----GQADAEKAKSTKNQRKTKGAKGTFHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHLCLKT 293

  Fly   186 FHDAFLYTEHLNGHQNRRDMNQFFPCPECPQTFNKKALLKQHRTQVHLINRRFQCTICHEAFASL 250
            |....|...|:|.|...|.    :.|.:|...|.....|.:||...|...:.|:|::|..|....
Human   294 FRTVTLLRNHVNTHTGTRP----YKCNDCNMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEA 354

  Fly   251 GAKLRHDKAHKNERPYPCLECGMIFSSVSELQNHFSTHSKQIRKFRCEPCNMDFITRRGLVAHTK 315
            ....||.::|..|||:.|.:|........:|:.|..|||.: :.:.|..|:..|.....:..|..
Human   355 SKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGE-KPYECHICHTRFTQSGTMKIHIL 418

  Fly   316 TAPHKRLAKY 325
            ....:.:.||
Human   419 QKHGENVPKY 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14667NP_001014607.1 zf-AD 6..80 CDD:214871
C2H2 Zn finger 179..199 CDD:275368 6/19 (32%)
C2H2 Zn finger 211..232 CDD:275368 6/20 (30%)
C2H2 Zn finger 240..260 CDD:275368 5/19 (26%)
zf-C2H2_8 243..313 CDD:292531 18/69 (26%)
C2H2 Zn finger 268..288 CDD:275368 4/19 (21%)
C2H2 Zn finger 297..316 CDD:275368 4/18 (22%)
CTCFLNP_001255972.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..55
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 221..250 9/37 (24%)
COG5048 <259..403 CDD:227381 36/148 (24%)
C2H2 Zn finger 259..279 CDD:275368 3/19 (16%)
zf-H2C2_2 271..296 CDD:290200 4/24 (17%)
C2H2 Zn finger 287..307 CDD:275368 6/19 (32%)
zf-H2C2_2 300..324 CDD:290200 7/27 (26%)
C2H2 Zn finger 315..333 CDD:275368 5/17 (29%)
C2H2 Zn finger 344..364 CDD:275368 5/19 (26%)
zf-H2C2_2 357..378 CDD:290200 8/20 (40%)
C2H2 Zn finger 372..392 CDD:275368 4/19 (21%)
zf-H2C2_2 385..409 CDD:290200 8/24 (33%)
C2H2 Zn finger 400..417 CDD:275368 3/16 (19%)
C2H2 Zn finger 430..448 CDD:275368
C2H2 Zn finger 460..480 CDD:275368
C2H2 Zn finger 488..508 CDD:275368
zf-H2C2_2 500..525 CDD:290200
C2H2 Zn finger 516..534 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..630
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24406
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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