DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hd and DONSON

DIOPT Version :9

Sequence 1:	NP_001303424.1	Gene:	hd / 40642	FlyBaseID:	FBgn0086695	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_060083.1	Gene:	DONSON / 29980	HGNCID:	2993	Length:	566	Species:	Homo sapiens

Alignment Length:	618	Identity:	194/618 - (31%)
Similarity:	278/618 - (44%)	Gaps:	130/618 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RPDDFIKLQRLKQKKNKLAARVSNNNNRRPRHQVDETDKSKLLEAKL------------------ 59
            :|.:.::|:|.:.:....||       ..||...:...:...|.|.|
Human    14 KPPEVVRLRRKRARSRGAAA-------SPPRELTEPAARRAALVAGLPLRPFPAAGGRGGGSGGG 71

  Fly    60 -AQKRKNPFAKSTADAKKLRVD--PQLADLEPVVTASSCFVRETPTRPAPAKFVLQKYD------ 115
             |..|:||||         |:|  |::|...|...|     ||.|..|.|.....|:.|
Human    72 PAAARRNPFA---------RLDNRPRVAAEPPDGPA-----REQPEAPVPFLDSNQENDLLWEEK 122

  Fly   116 ----------PQAFAKLFQHPQINAEDEDDAELAARQKHTAHLPVDWSLKTRARFFCPTELP--- 167
                      ||.....|..|.|.:            ..:..||||||:|||..|  .:..|
Human   123 FPERTTVTELPQTSHVSFSEPDIPS------------SKSTELPVDWSIKTRLLF--TSSQPFTW 173

  Fly   168 AIQLKTSQLASGLTSFVRCMDPQRTESTLD--ISDATR--FNQCNYYWQHPHLPWLTLYPRTAKE 228
            |..||..:.|.||....|..:....:|..|  :|...|  |.|...||.||.|.||.|:||...:
Human   174 ADHLKAQEEAQGLVQHCRATEVTLPKSIQDPKLSSELRCTFQQSLIYWLHPALSWLPLFPRIGAD 238

  Fly   229 NVGVVVGERE--------RKALAEEWDFSFRGLFQLLRARQCPYFYLCANTFTVLFRAAGVGGRP 285
            .  .:.|:..        :..|..:|..||..|:.||:.:.|||||:|...|||||||||:.|..
Human   239 R--KMAGKTSPWSNDATLQHVLMSDWSVSFTSLYNLLKTKLCPYFYVCTYQFTVLFRAAGLAGSD 301

  Fly   286 ESHALVTPSTRGMRQALRQEGIEFSMPLKSDNSGNAHDNSFNEESTTTSLGPEAGEDAPPPAQED 350
            ...||::|:|||:|:|:|.||||||:||..: ||:.     .|.::.||||  .||:   .|..|
Human   302 LITALISPTTRGLREAMRNEGIEFSLPLIKE-SGHK-----KETASGTSLG--YGEE---QAISD 355

  Fly   351 EDDDE--DWLESLGVDERELRR--IQSSHARKQQAAEMREDFSDNSLLLVDGVECQGFFSYLLNA 411
            ||::|  .|||.:||.:: :::  |.|...||:: .|::.|....|::||.|:......::|:|:
Human   356 EDEEESFSWLEEMGVQDK-IKKPDILSIKLRKEK-HEVQMDHRPESVVLVKGINTFTLLNFLINS 418

  Fly   412 KSAISTVGRLAGVPPTLLSPVAFPKATMQHLVPRSKKVRLDGV----DYFSIDIKGLILPTFLPS 472
            ||.::|.|..||:||||||||||..||||.|..||..|:...:    |.||::|.|.|:|..|.|
Human   419 KSLVATSGPQAGLPPTLLSPVAFRGATMQMLKARSVNVKTQALSGYRDQFSLEITGPIMPHSLHS 483

  Fly   473 VAELLSETRQ-MFSSTLASSINTLAFSKATQ--KLLETPETPQSDAEGEDAAGQVFGEQNLSECG 534
            :..||..::. .||:.|.....|..|:...|  |:|:....                .:.|:.||
Human   484 LTMLLKSSQSGSFSAVLYPHEPTAVFNICLQMDKVLDMEVV----------------HKELTNCG 532

  Fly   535 LLPAVVGSICRTGQHAVGLLERVCYQRDEGYAW 567
            |.|..:..:.:........|..|.. ||..|.|
Human   533 LHPNTLEQLSQIPLLGKSSLRNVVL-RDYIYNW 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hd	NP_001303424.1	None
DONSON	NP_060083.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..110		27/116 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158977
Domainoid	1	1.000	211	1.000	Domainoid score	I2795
eggNOG	1	0.900	-	-		E1_KOG4734
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32350
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3655
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49434
OrthoDB	1	1.010	-	-		D479613at2759
OrthoFinder	1	1.000	-	-		FOG0007554
OrthoInspector	1	1.000	-	-		oto88908
orthoMCL	1	0.900	-	-		OOG6_105661
Panther	1	1.100	-	-	LDO	PTHR12972
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7585
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770