Protein Alignment Cerk and SPHK1

DIOPT Version :9

• Sequence 1: NP_649530.2
• Gene: Cerk / 40640
• FlyBaseID: FBgn0037315
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: NP_892010.2
• Gene: SPHK1 / 8877
• HGNCID: 11240
• Length: 470
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 106/472 - (22%)
• Similarity: 171/472 - (36%)
• Gaps: 124/472 - (26%)

  Fly    81 PLP---PDSPAQPGGICSYGPQSHVLHLDDVVSIRSGDTKASSLKPPSPPGSERSSGCSGDVAQG 142
            |||   |..||..|                      .|..|.:...|...|...|..|  |...|
Human    14 PLPLAAPRGPAAAG----------------------NDAGAPAATAPGGEGEPHSRPC--DARLG 54

  Fly   143 KPTSQYLTINYAMRLSKSQTDCNRWELRRLTFFNSDPYIVRQWDQELQIRLHSSSPTRMRVR--R 205
            . |.:.|....|...|........|                |.:..:::...:..|..:..|  |
Human    55 S-TDKELKAGAAATGSAPTAPGTPW----------------QREPRVEVMDPAGGPRGVLPRPCR 102

  Fly   206 LLVFINPYGGRKAGAQTYERHVRPIFQLAGVDATCITTQRANQVKDILLSHDLGVYDAVCCVGGD 270
            :||.:||.||:....|.:..||:|:...|.:..|.:.|:|.|..::::.|.:||.:||:..:.||
Human   103 VLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGD 167

  Fly   271 GTVAEVINGLIFRQMRELGLDEQRPPYIPRPALPVGVIPAGSTDTIAYSMHGTA--------DVR 327
            |.:.||:|||:           :||.:......|:..:||||.:.:|.|::..|        |:.
Human   168 GLMHEVVNGLM-----------ERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLL 221

  Fly   328 TAAIHVILGQHRG-LDVCSVSNGQSLLRFCASVLSYGYLGDVAAQSENYRWMGPRRY-------- 383
            |....::..:... :::.|:.....|..|....|::|::.||..:||.||.:|..|:
Human   222 TNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRL 286

  Fly   384 ----EYSGVKAFL----------------NNRGYDAELRMLEEP-----------DLLLTTPL-- 415
                .|.|..|:|                .....||.|..||||           |.:|...|
Human   287 AALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLH 351

  Fly   416 ----EDIPQSPDSVCSLGESVPSVCYANCQRCSFASSIQEQRSSLFIQEESKEAERNQQVETEDS 476
                .::..:|...|:.|  |..:.|..      |...:.....||:     ..|:.:.:|.|..
Human   352 SHLGSEMFAAPMGRCAAG--VMHLFYVR------AGVSRAMLLRLFL-----AMEKGRHMEYECP 403

  Fly   477 HLAASEAALLRPRPRPG 493
            :|........|..|:.|
Human   404 YLVYVPVVAFRLEPKDG 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cerk	NP_649530.2	PLN02204	157..658	CDD:215126	88/393 (22%)
SPHK1	NP_892010.2	PLN02958	<97..431	CDD:215517	84/348 (24%)
		DAGK_cat	102..>207	CDD:279163	38/115 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681139at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.780