Protein Alignment Cerk and CERK

DIOPT Version :9

• Sequence 1: NP_649530.2
• Gene: Cerk / 40640
• FlyBaseID: FBgn0037315
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: NP_073603.2
• Gene: CERK / 64781
• HGNCID: 19256
• Length: 537
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 198/629 - (31%)
• Similarity: 296/629 - (47%)
• Gaps: 129/629 - (20%)

  Fly    59 QQLVWERLQKIKQSPQGNEAKAPL-----PPDSPAQPGGICSYGPQSHVLHLD--DVVSIRSGDT 116
            |.::|.:.|:...|.:  .|:|.|     |......||......|.|.::.::  ||.....|..
Human    11 QSVLWVKQQRCAVSLE--PARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEETDVHGKHQGSG 73

  Fly   117 KASSLKPPSPPGSERSSGCSGDVAQGKPTSQYLTINYAMRLSKSQTDCNRWELRRLTFFNSDPYI 181
            |...::.|                      ...|::...|..:     :||:..::||:..:..:
Human    74 KWQKMEKP----------------------YAFTVHCVKRARR-----HRWKWAQVTFWCPEEQL 111

  Fly   182 VRQWDQELQIRLHSSSPTRMRVRRLLVFINPYGGRKAGAQTYERHVRPIFQLAGVDATCITTQRA 246
            ...|.|.|:..|...:   .|.:.|||||||:||:..|.:.|||.|.|:|.||.:....|.|:.|
Human   112 CHLWLQTLREMLEKLT---SRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHA 173

  Fly   247 NQVKDILLSHDLGVYDAVCCVGGDGTVAEVINGLIFRQMRELGLDEQRPPYIPRP-ALPVGVIPA 310
            ||.|:.|...::..||.:.||||||..:||::|||.|..|..|:|:..|..:..| :|.:|:|||
Human   174 NQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPA 238

  Fly   311 GSTDTIAYSMHGTADVRTAAIHVILGQHRGLDVCSVSNGQSLLRFCASVLSYGYLGDVAAQSENY 375
            ||||.:.||..||:|..|:|:|:::|....:||.||.:..:|||:..|:|.||:.||:...||..
Human   239 GSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKK 303

  Fly   376 RWMGPRRYEYSGVKAFLNNRGYDAELRMLEEPDLLLTTPLEDIPQSPDSVCSLGESVPSVCYANC 440
            ||:|..||::||:|.||::..|:..:..|         |.:....||      .:..|  |.|.|
Human   304 RWLGLARYDFSGLKTFLSHHCYEGTVSFL---------PAQHTVGSP------RDRKP--CRAGC 351

  Fly   441 QRCSFASSIQEQRSSLFIQEESKEA----ERNQQVETEDSHLAASEAALLRPRPRPGNLRLPTGS 501
            ..|        ::|...::||.|:|    |..:.||
Human   352 FVC--------RQSKQQLEEEQKKALYGLEAAEDVE----------------------------- 379

  Fly   502 ISSMRNLGNDQWKVVRGNFFMICGANITCACARSPNGISRYSHLGDGCLDLILVKKTSLLNNVRF 566
                      :|:||.|.|..|...|::|||.|||.|:|..:|||||..||||::|.|..|.:||
Human   380 ----------EWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLILIRKCSRFNFLRF 434

  Fly   567 LLNTAGRSGDIRNLPFVEVYRTREFRFRTFSASEEDYSLAGS--------CQPITPPEEMTAHSS 623
            |:....:. |..:..||||||.::|:|.:....:||..|...        |         ::|.|
Human   435 LIRHTNQQ-DQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRFGHIC---------SSHPS 489

  Fly   624 ---STEFSSWNCDGEVVTDLDITMRSHCQLIEVFMRGPHSYSKP 664
               :...|||||||||:....|.:|.||||:.:|.||.....||
Human   490 CCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKP 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cerk	NP_649530.2	PLN02204	157..658	CDD:215126	176/516 (34%)
CERK	NP_073603.2	Required for binding to sulfatide and phosphoinositides. /evidence=ECO:0000269|PubMed:19168031	1..125		27/142 (19%)
		Essential for enzyme activity. /evidence=ECO:0000269|PubMed:16269826	1..115		23/132 (17%)
		PLN02204	55..528	CDD:215126	185/576 (32%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9NYA1	195..198		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146144
Domainoid	1	1.000	145	1.000	Domainoid score	I4601
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11247
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D165368at33208
OrthoFinder	1	1.000	-	-		FOG0004595
OrthoInspector	1	1.000	-	-		oto88943
orthoMCL	1	0.900	-	-		OOG6_106125
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3210
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.760