DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cerk and Sphk2

DIOPT Version :9

Sequence 1:	NP_649530.2	Gene:	Cerk / 40640	FlyBaseID:	FBgn0037315	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001166032.1	Gene:	Sphk2 / 56632	MGIID:	1861380	Length:	617	Species:	Mus musculus

Alignment Length:	693	Identity:	156/693 - (22%)
Similarity:	244/693 - (35%)	Gaps:	196/693 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 AKAPLPPDSPAQP---GGICSY---GPQ------SHVLHLDDVVSIRSGDTKASSLKPPSPP--- 127
            |..||.|.:.:.|   |...||   ||:      :..||:.   .:|.        ||.:.|
Mouse     2 APPPLLPVAASTPILHGEFGSYPANGPRFALTLTTQALHIQ---RLRP--------KPEARPRDG 55

  Fly   128 --GSERSSGCSGDVAQGKP--TSQYLTI--------------------NYAMRLSKSQTDCNRWE 168
              ..:..||| |.:....|  |:.|..|                    :.|....:::.:..||.
Mouse    56 LVSLDEVSGC-GTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRADGATTYEENRAEAQRWA 119

  Fly   169 LRRLTFFNSDPYIVRQWDQELQIRLHSSSPTRMRVRRLLVFINPYGGRKAGAQTYERHVRPIFQL 233
            ..........|.   ..|||:...|....|      |||:.:||:|||....|....||.|:...
Mouse   120 TALTCLLRGVPL---SGDQEITPELLPRKP------RLLILVNPFGGRGLAWQRCMDHVVPMISE 175

  Fly   234 AGVDATCITTQRANQVKDILLSHDLGVYDAVCCVGGDGTVAEVINGLIFRQMRELGLDEQRPPYI 298
            ||:....|.|:|.|..::::....|..::.:..|.|||.:.||:|||:           .||.:.
Mouse   176 AGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEVLNGLL-----------DRPDWE 229

  Fly   299 PRPALPVGVIPAGSTDTIAYSM--HGTADVRTAAIHVIL---------GQHRGLDVCSV--SNGQ 350
            ....:|:||:|.||.:.:|.::  ||..: :...:.::|         |.| .||:.||  ::|.
Mouse   230 DAVRMPIGVLPCGSGNALAGAVNHHGGFE-QVVGVDLLLNCSLLLCRGGSH-PLDLLSVTLASGS 292

  Fly   351 SLLRFCASVLS--YGYLGDVAAQSENYRWMGPRRYEYSGVKAFLNNRGYDAELRML---EEPDLL 410
            .    |.|.||  :|:|.||...||.:|.:|..|:....|....:...|...|..|   .||  .
Mouse   293 R----CFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLASLHTYRGRLSYLPATTEP--A 351

  Fly   411 LTTPLEDIPQSPDSVCSLGESVPSVCYANCQRCSFASSIQEQRSSL----FIQEESKEAERNQQV 471
            |..|...:|::...:.......|:..::...|     |:.:....|    .:...|.|...:..:
Mouse   352 LPIPGHSLPRAKSELVLAPAPAPAATHSPLHR-----SVSDLPLPLPQPALVSPGSPEPLPDLSL 411

  Fly   472 E------------------TEDSHLAASEAAL----LRP-------RPRPGNLRLPTGSISSMRN 507
            .                  :.|..|.:|..||    |.|       .|.......||.|......
Mouse   412 NGGGPELTGDWGGAGDAPLSPDPLLPSSPNALKTAQLSPIAEGPPEMPASSGFLPPTHSAPEAST 476

  Fly   508 LG-------------NDQWKVVRGNFFMICGANITCACA---RSPNGISRYSHLGDGCLDLILVK 556
            .|             ...|..:.|.|.::.|...:..||   .:|     ::...||.:.|..|:
Mouse   477 WGPVDHLLPPLGSPLPQDWVTIEGEFVLMLGILPSHLCADLMAAP-----HARFDDGVVHLCWVR 536

  Fly   557 ----KTSLLNNVRFLLNTAGRSGDIRNL--PFVEVYRTREFRFRTFSASEEDYSLAGSCQPITPP 615
                :.:||   |.||  |...|:..:|  |.:.....|.||.                :|:||.
Mouse   537 SGISRAALL---RILL--AMEHGNHFSLGCPHLGYAAARAFRL----------------EPLTPR 580

  Fly   616 EEMTAHSSSTEFSSWNCDGEVVTDLDITMRSHCQLIEVFMRGP 658
            ..:|.            |||:|....|..:.|..| ...:.||
Mouse   581 GLLTV------------DGELVEYGPIQAQVHPGL-ATLLTGP 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cerk	NP_649530.2	PLN02204	157..658	CDD:215126	129/573 (23%)
Sphk2	NP_001166032.1	Required for binding to sulfatide and phosphoinositides and for membrane localization. /evidence=ECO:0000250	1..140		31/152 (20%)
		NLS. /evidence=ECO:0000269\|PubMed:12954646	87..95		0/7 (0%)
		PLN02958	<142..608	CDD:215517	122/534 (23%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9NYA1	210..213		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..472		17/105 (16%)
		NES. /evidence=ECO:0000250\|UniProtKB:Q9NRA0	381..390		2/13 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681139at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.780