DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cerk and CERKL

DIOPT Version :10

Sequence 1:NP_649530.2 Gene:Cerk / 40640 FlyBaseID:FBgn0037315 Length:687 Species:Drosophila melanogaster
Sequence 2:NP_001025482.1 Gene:CERKL / 375298 HGNCID:21699 Length:558 Species:Homo sapiens


Alignment Length:685 Identity:158/685 - (23%)
Similarity:256/685 - (37%) Gaps:213/685 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 VAPISSTSASKFTPCSASDHNVLLNN-FQLKKKSYRVLLHGQQLVWERLQKIKQSPQGNEAKAPL 82
            |.|...||..:   ..|:...:||.. |::.:.|..|:|..:.|.|..:|               
Human    28 VPPALLTSPQQ---TEAAAERILLRGIFEIGRDSCDVVLSERALRWRPIQ--------------- 74

  Fly    83 PPDSPAQPGGICSYG--PQSHVLHLDDVVSIRSGDTKASSLKPPSPPGSERSSGCSG-------D 138
                |.:|.|...|.  .:...:.|.|:.|::        ||.......:||....|       .
Human    75 ----PERPAGDSKYDLLCKEEFIELKDIFSVK--------LKRRCSVKQQRSGTLLGITLFICLK 127

  Fly   139 VAQGKPTSQYLTINYAMRLSKSQTDCNRWELRRLTFFNSDPYIVRQWDQELQIRLHSSSPTRMRV 203
            ..|.|..:..|.:     ::.|:..|:.|              .||:.:.|     :..|.  |.
Human   128 KEQNKLKNSTLDL-----INLSEDHCDIW--------------FRQFKKIL-----AGFPN--RP 166

  Fly   204 RRLLVFINPYGGRKAGAQTYERHVRPIFQLAGVDATCITTQRANQVKDILLSHDLGVYD------ 262
            :.|.:.:||...:|...|.|...|.|:.:|||:.......:.......:|...:|..:|      
Human   167 KSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGGHRKP 231

  Fly   263 --------------------AVCCVGGDGTVAEVINGLIFRQMRELGLDEQRPPYIPRPALPVGV 307
                                :|.||||||:.:||.:.|:.|..:..|::..|.....|..||:|:
Human   232 LFAIHWSVQRLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGL 296

  Fly   308 IPAGSTDTIAYSMHGTADVRTAAIHVILGQHRGLDVCSVSNGQSLLRFCASVLSYGYLGDVAAQS 372
            ||||||:.:|:|:||...|.||.:|:|:|..:.:|||:.|....||||..|.: :|:.|...|.:
Human   297 IPAGSTNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAM-FGFGGRTLALA 360

  Fly   373 ENYRWMGP-RRYEYSGVKAFLNNRGYDAELRMLEEPDLLLTTPLEDIPQSPDSVCSLGESVPSVC 436
            |.||||.| :|.:::.|||....:..|.|:..|                                
Human   361 EKYRWMSPNQRRDFAVVKALAKLKAEDCEISFL-------------------------------- 393

  Fly   437 YANCQRCSFASS--IQEQRSSLFIQEESKEAERNQQVETEDSHLAASEAALLRPRPRPGNLRLPT 499
                   .|.||  :||:|:.                                            
Human   394 -------PFNSSDDVQERRAQ-------------------------------------------- 407

  Fly   500 GSISSMRNLGNDQWKVVRGNFFMICGANITCACARSPNGISRYSHLGDGCLDLILVKKTSLLNNV 564
               .|.::..||||::::|.|..:....|.|.|:.:|.|::..:.|.:|.:.||:.:.||....:
Human   408 ---GSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFI 469

  Fly   565 RFLLNTAGRSGDIRNLPFVEVYRTREFRFRTFS-------ASEEDYSLAGSCQPITPPEEMTAHS 622
            :.|...|...... |.||||.|...|.:....:       ..|||.:.:.:|.|           
Human   470 KHLKRYASVKNQF-NFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASENCFP----------- 522

  Fly   623 SSTEFSSWNCDG---EVVTDLDITMRSHCQLIEVF 654
                   ||.||   ||.:::.|  |.|.:||.::
Human   523 -------WNVDGDLMEVASEVHI--RLHPRLISLY 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CerkNP_649530.2 DAGK_cat 157..658 CDD:445337 129/537 (24%)
CERKLNP_001025482.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 3/7 (43%)
Nuclear localization signal 1. /evidence=ECO:0000255 2..9
Nuclear localization signal 2 102..106 2/11 (18%)
PLN02958 143..462 CDD:215517 102/426 (24%)
CERK_C 346..555 CDD:466025 66/311 (21%)
Blue background indicates that the domain is not in the aligned region.

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