DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cerk and Cerk

DIOPT Version :9

Sequence 1:	NP_649530.2	Gene:	Cerk / 40640	FlyBaseID:	FBgn0037315	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001128333.1	Gene:	Cerk / 300129	RGDID:	1305019	Length:	531	Species:	Rattus norvegicus

Alignment Length:	618	Identity:	196/618 - (31%)
Similarity:	300/618 - (48%)	Gaps:	121/618 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 QQLVWERLQKIKQSPQGNEAKAPL-----PPDSPAQPGGICSYGPQSHVLHLDDVVSIRSGDT-- 116
            |.::|.:.|:...|.:  .|:|.|     |...|:.|      .|.::.:.:.:::::...:.
  Rat    11 QSVLWVKQQRCAVSLE--PARALLRWWRSPEPGPSAP------DPDAYSVPVSEIIAVEEKEVHQ 67

  Fly   117 KASSLKPPSPPGSERSSGCSGDVAQGKPTSQYLTINYAMRLSKSQTDCNRWELRRLTFFNSDPYI 181
            |.||        :.|........|        .|::...|...     :||:..|:||:::|..:
  Rat    68 KQSS--------NGRWHRMENPFA--------FTVHCVKRARH-----HRWKWARVTFWSADEQL 111

  Fly   182 VRQWDQELQIRLHSSSPTRMRVRRLLVFINPYGGRKAGAQTYERHVRPIFQLAGVDATCITTQRA 246
            .:.|.|.|:..|.:.:   .|.:.|||||||:||:..|...||:.|.|:|.||.:....|.|:.|
  Rat   112 CQLWLQTLRELLENLT---SRPKHLLVFINPFGGKGQGKHIYEKKVAPLFTLASITTEIIITEHA 173

  Fly   247 NQVKDILLSHDLGVYDAVCCVGGDGTVAEVINGLIFRQMRELGLDEQRPPYIPRPA-LPVGVIPA 310
            ||.|:.|...:...||.:.||||||..:||::|:|.:..:..|:|...|..:..|: |.:|:|||
  Rat   174 NQAKETLYEINTDSYDGIVCVGGDGMFSEVLHGVIGKTQQSAGVDPNHPRAVLVPSTLRIGIIPA 238

  Fly   311 GSTDTIAYSMHGTADVRTAAIHVILGQHRGLDVCSVSNGQSLLRFCASVLSYGYLGDVAAQSENY 375
            ||||.:.||..||.|..|:|:|:|:|....:||.||.:..:|||:..|:|.||:.||:...||..
  Rat   239 GSTDCVCYSTVGTNDAETSALHIIIGDSLAIDVSSVHHNSTLLRYSVSLLGYGFYGDLIKDSEKK 303

  Fly   376 RWMGPRRYEYSGVKAFLNNRGYDAELRMLEEPDLLLTTPLEDIPQSPDSVCSLGESVPSVCYANC 440
            ||||..||::||:||||:::.|:..:..|         |.:....||      .:..|  |.|.|
  Rat   304 RWMGLVRYDFSGLKAFLSHQYYEGTVSFL---------PAQHTVGSP------RDQKP--CRAGC 351

  Fly   441 QRCSFASSIQEQRSSLFIQEESKEA----ERNQQVETEDSHLAASEAALLRPRPRPGNLRLPTGS 501
            ..|        ::|...::||.|:|    |..::||
  Rat   352 SVC--------RQSKRQLEEEQKKALYGLENAEEVE----------------------------- 379

  Fly   502 ISSMRNLGNDQWKVVRGNFFMICGANITCACARSPNGISRYSHLGDGCLDLILVKKTSLLNNVRF 566
                      :|:||.|.|..|...|::|||.|||.|:|.::|||||..||||::|.|..|.:||
  Rat   380 ----------EWQVVCGKFLAINSTNMSCACPRSPGGLSPFAHLGDGSSDLILIRKCSRFNFLRF 434

  Fly   567 LLNTAGRSGDIRNLPFVEVYRTREFRFRTFSASEEDYSLA-------GSCQPITPPEEMTAHSSS 624
            |:....:. |.....||||||.::|:|.:....::|..|.       |......||     .:..
  Rat   435 LIRHTNQE-DQFGFTFVEVYRVKKFQFTSKHVEDDDNDLKELEKQKFGQICKDNPP-----CACP 493

  Fly   625 TEFSSWNCDGEVVTDLDITMRSHCQLIEVFMRG 657
            |..|||||||||:....|.:|.||||:.:|.||
  Rat   494 TSRSSWNCDGEVLHSPAIEVRVHCQLVRLFARG 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cerk	NP_649530.2	PLN02204	157..658	CDD:215126	178/513 (35%)
Cerk	NP_001128333.1	DAGK_cat	55..528	CDD:412815	152/479 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339912
Domainoid	1	1.000	150	1.000	Domainoid score	I4296
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11247
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2697
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D165368at33208
OrthoFinder	1	1.000	-	-		FOG0004595
OrthoInspector	1	1.000	-	-		oto96076
orthoMCL	1	0.900	-	-		OOG6_106125
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3210
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760