DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cerk and SPAC4A8.07c

DIOPT Version :9

Sequence 1:	NP_649530.2	Gene:	Cerk / 40640	FlyBaseID:	FBgn0037315	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_593818.1	Gene:	SPAC4A8.07c / 2543328	PomBaseID:	SPAC4A8.07c	Length:	458	Species:	Schizosaccharomyces pombe

Alignment Length:	501	Identity:	128/501 - (25%)
Similarity:	188/501 - (37%)	Gaps:	129/501 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PTSQYLTINYAMRLSKSQTDCNRWELRRLTFFNSDPYIVRQWDQELQIRLHSSSPTRMRVRRLLV 208
            |.|  :|::|..|.||..|.|  |    :.|       |...||..:..|..:.....|.||.:|
pombe    61 PNS--VTLSYVSRSSKVATKC--W----VDF-------VENSDQFCEYLLDVAYKGIKRSRRFIV 110

  Fly   209 FINPYGGRKAGAQTYERHVRPIFQLAGVDATCITTQRANQVKDILLSHDLGVYDAVCCVGGDGTV 273
            ||||:||:......:|....|:|..|......:.|:|.:..|.|..:.|:|.||.:..|||||..
pombe   111 FINPHGGKGKAKHIWESEAEPVFSSAHSICEVVLTRRKDHAKSIAKNLDVGSYDGILSVGGDGLF 175

  Fly   274 AEVINGLIFRQMRELGLDEQRPPYIPRPALPVGVIPAGSTDTIAYSMHGTADVRTAAIHVILGQH 338
            .||||||           .:|..|:....|||.:||.||.:..:|:..|.......|:.::.|:.
pombe   176 HEVINGL-----------GERDDYLEAFKLPVCMIPGGSGNAFSYNATGQLKPALTALEILKGRP 229

  Fly   339 RGLDVCSV-SNGQSLLRFCASVLSYGYLGDVAAQSENYRWMGPRRYEYSGVKAFLNNRGYDAELR 402
            ...|:.:. ..|:....|..:  :||.:.|....:||:|:||..|       |:|   |:  .||
pombe   230 TSFDLMTFEQKGKKAYSFLTA--NYGIIADCDIGTENWRFMGENR-------AYL---GF--FLR 280

  Fly   403 MLEEPDLLLTTPLEDIPQSPDSVCSLGESVPSVCYANCQRCSFASSIQ---EQRSSLFIQEESKE 464
            :.               |.||..||:...|.|         |..:.|:   |:..:|....||.:
pombe   281 LF---------------QKPDWKCSIEMDVVS---------SDRTEIKHMYEKSKNLAPMSESSD 321

  Fly   465 AERNQQVETEDSHLAASE-------AALLRPRPRPGNLRLPTGSISSMRNLGNDQWKVVRGNFFM 522
            :::......| |||...|       .|.|.|...|.....|..|        ||
pombe   322 SDKTVSTSPE-SHLLTFEINDLSIFCAGLLPYIAPDAKMFPAAS--------ND----------- 366

  Fly   523 ICGANITCACARSPNGISRYSHLGDGCLDLILVK----KTSLLNNVRFLLNTAGRSGDIRNLPFV 583
                                    ||.:|:::|.    :.|||:....|.|     |.......:
pombe   367 ------------------------DGLIDVVIVYSKQFRKSLLSMFTQLDN-----GGFYYSKHL 402

  Fly   584 EVYRTREFRFRTFSASEEDY-SLAGSCQPITPPEEMTAHSSSTEFS 628
            ..|:.|.|||...:..:..| :|.|...|:.|.|...|....|..|
pombe   403 NYYKVRSFRFTPVNTGKRHYFALDGESYPLEPFECRVAPKLGTTLS 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cerk	NP_649530.2	PLN02204	157..658	CDD:215126	123/488 (25%)
SPAC4A8.07c	NP_593818.1	LCB5	104..442	CDD:224513	111/435 (26%)
SPAC4A8.07c	NP_593818.1	DAGK_cat	107..236	CDD:279163	45/139 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	78	1.000	Domainoid score	I2404
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840