DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cerk and Cerk

DIOPT Version :9

Sequence 1:	NP_649530.2	Gene:	Cerk / 40640	FlyBaseID:	FBgn0037315	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	XP_036015253.1	Gene:	Cerk / 223753	MGIID:	2386052	Length:	564	Species:	Mus musculus

Alignment Length:	582	Identity:	185/582 - (31%)
Similarity:	274/582 - (47%)	Gaps:	136/582 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 ASSLKP--------------PSPPGS-------------ERSSGCSGDVAQGK------PTSQYL 149
            |.||:|              ||.||:             |....|....:.|:      |.:  .
Mouse    22 AVSLEPARALLRWWRSPEPGPSAPGADARSVLVSEIIAVEEKDDCEKHASSGRWHKMENPFA--F 84

  Fly   150 TINYAMRLSKSQTDCNRWELRRLTFFNSDPYIVRQWDQELQIRLHSSSPTRMRVRRLLVFINPYG 214
            |::...|:..     :||:..|:||:::|..:...|.|.|:..|.|.:   .|.:.|||||||:|
Mouse    85 TVHRVKRVRH-----HRWKWARVTFWSADEQLCHLWLQTLRGLLESLT---SRPKHLLVFINPFG 141

  Fly   215 GRKAGAQTYERHVRPIFQLAGVDATCITTQRANQVKDILLSHDLGVYDAVCCVGGDGTVAEVING 279
            |:..|.:.||:.|.|:|.||.:....|.|:.|||.|:.|...:...||.:.||||||..:||::|
Mouse   142 GKGQGKRIYEKTVAPLFTLASITTEIIITEHANQAKETLYEINTDSYDGIVCVGGDGMFSEVLHG 206

  Fly   280 LIFRQMRELGLDEQRPPYIPRPA-LPVGVIPAGSTDTIAYSMHGTADVRTAAIHVILGQHRGLDV 343
            :|.|..:..|:|...|..:..|: |.:|:|||||||.:.||..||.|..|:|:|:|:|....:||
Mouse   207 VIGRTQQSAGIDPNHPRAVLVPSTLRIGIIPAGSTDCVCYSTVGTNDAETSALHIIIGDSLAIDV 271

  Fly   344 CSVSNGQSLLRFCASVLSYGYLGDVAAQSENYRWMGPRRYEYSGVKAFLNNRGYDAELRMLEEPD 408
            .||....:|||:..|:|.||:.||:...||..||||..||::||:|.||:::.|:..|..|
Mouse   272 SSVHYHNTLLRYSVSLLGYGFYGDLIKDSEKKRWMGLVRYDFSGLKTFLSHQYYEGTLSFL---- 332

  Fly   409 LLLTTPLEDIPQSPDSVCSLGESVPSVCYANCQRCSFASSIQEQRSSLFIQEESKEA----ERNQ 469
                 |.:....||      .::.|  |.|.|..|        ::|...::||.|:|    |..:
Mouse   333 -----PAQHTVGSP------RDNKP--CRAGCFVC--------RQSKQQLEEEEKKALYGLENAE 376

  Fly   470 QVETEDSHLAASEAALLRPRPRPGNLRLPTGSISSMRNLGNDQWKVVRGNFFMICGANITCACAR 534
            ::|                                       :|:|..|.|..|...|::|||.|
Mouse   377 EME---------------------------------------EWQVTCGKFLAINATNMSCACPR 402

  Fly   535 SPNGISRYSHLGDGCLDLILVKKTSLLNNVRFLLNTAGRSGDIRNLPFVEVYRTREFRFRTFSAS 599
            ||.|:|.::|||||..||||::|.|..|.:|||:....:. |..:..||||||.::|.|.:....
Mouse   403 SPGGLSPFAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQE-DQFDFTFVEVYRVKKFHFTSKHVE 466

  Fly   600 EED--------YSLAGSCQPITPPEEMTAHSSSTEFSSWNCDGEVVTDLDITMRSHCQLIEV 653
            :||        ......|      ::..:.:.|...|||||||||:         |...|||
Mouse   467 DEDNDSKEQEKQKFGKIC------KDRPSCTCSASRSSWNCDGEVM---------HSPAIEV 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cerk	NP_649530.2	PLN02204	157..658	CDD:215126	171/510 (34%)
Cerk	XP_036015253.1	DAGK_cat	84..466	CDD:412815	135/386 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836247
Domainoid	1	1.000	143	1.000	Domainoid score	I4659
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11247
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2841
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D165368at33208
OrthoFinder	1	1.000	-	-		FOG0004595
OrthoInspector	1	1.000	-	-		oto92510
orthoMCL	1	0.900	-	-		OOG6_106125
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	1	1.000	-	-		X3210
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790