DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rps6kb1b and S6k

DIOPT Version :9

Sequence 1:	NP_998241.1	Gene:	rps6kb1b / 406349	ZFINID:	ZDB-GENE-040426-2038	Length:	502	Species:	Danio rerio
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	302/511 - (59%)
Similarity:	354/511 - (69%)	Gaps:	53/511 - (10%)

- Green bases have known domain annotations that are detailed below.

Zfish     4 VFDIDL------DQPEENVSDDELEEAQINELMDQCSGFEFNMDDCEKIEISEDNVNQGTENIRP 62
            :||::|      |....:..||.:|...::...:.|.....:.:..|.|::.|:|||.|...:.|
  Fly    10 LFDLELHDLELQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIKLGP 74

Zfish    63 ECFELLRVLGKGGYGKVFQVRKVSGAATGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHP 127
            :.|||.:|||||||||||||||.:|....|.|||||||||.||.|.||||||:|||||||.||||
  Fly    75 KDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHP 139

Zfish   128 FIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRD 192
            |||:|:|||||.|||||||||||||||||.|||||||:|||.||||:||.:||||||:.||||||
  Fly   140 FIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRD 204

Zfish   193 LKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALM 257
            ||||||:|:.||||||||||||||.|.:|.|||||||||||||||||.||||.:|||||||||||
  Fly   205 LKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALM 269

Zfish   258 YDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQT 322
            :|||||.||||.|||||||:.|||.|||||.|||.|||||::||:||....|||:||.||..||.
  Fly   270 FDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQI 334

Zfish   323 HPFFRHVNWDDLLARKVEPPFKPFLQFAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTY 387
            ||||:||||||:|||::|||.||.|:..:||||||::||.|.|||||||:|||||||.:|.||||
  Fly   335 HPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTY 399

Zfish   388 VAPSVLENIKEKFSFEPKIRSPRRFLGSPRTPLSPIKFSGDCWPRGPTLPGSS-TLQSPT----- 446
            ||||:||::..  :.....|||||   :||                 .||.|| .||.|:
  Fly   400 VAPSILEDMHR--ANRMPARSPRR---TPR-----------------QLPDSSFRLQFPSANVGA 442

Zfish   447 --ELAMEVSSVDHMDVQAS---AEATAP------LPIRQPAGSNMGQFKQQAYPVI 491
              .|||      |...|.|   |.||.|      .|...||...|  ...|..|::
  Fly   443 NAPLAM------HGHSQRSGMFARATPPHHMQTFAPRPSPAQDEM--MDVQGLPMV 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rps6kb1b	NP_998241.1	S_TKc	65..326	CDD:214567	205/260 (79%)
rps6kb1b	NP_998241.1	STKc_p70S6K	68..390	CDD:270736	248/321 (77%)
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	246/320 (77%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	248/320 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573238
Domainoid	1	1.000	404	1.000	Domainoid score	I683
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81703
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1143
OMA	1	1.010	-	-		QHG51952
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0001793
OrthoInspector	1	1.000	-	-		otm24514
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	LDO	PTHR24351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1494
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770