DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hph and Egln3

DIOPT Version :9

Sequence 1:	NP_001287171.1	Gene:	Hph / 40633	FlyBaseID:	FBgn0264785	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_062244.2	Gene:	Egln3 / 54702	RGDID:	71019	Length:	355	Species:	Rattus norvegicus

Alignment Length:	260	Identity:	120/260 - (46%)
Similarity:	161/260 - (61%)	Gaps:	25/260 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 MGSGSERRYEDLCR---------NIISDMNQYGLSVVDDFLGMETGLKILNEVRSMYNAGAFQDG 237
            :||.||.....:.|         .|:..:::.|...:|:|||...|..:|..|:.::..||.:||
  Rat   111 LGSVSEMPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHYNGALRDG 175

  Fly   238 QVVTNQTPDAPAVRGDKIRGDKIKWVGGNEPGCSNVWYLTNQIDSVVYRVNTMKDNGILGNYHIR 302
            |:.   .|.| .|....:|||:|.|:||||.||..:.:|.:.||.:|....:.     ||.|:::
  Rat   176 QLA---GPRA-GVSKRHLRGDQITWIGGNEEGCEAINFLLSLIDRLVLYCGSR-----LGKYYVK 231

  Fly   303 ERTRAMVACYPGSGTHYVMHVDNPQKDGRVITAIYYLNINWDARESGGILRIRPTPGTTVADIEP 367
            ||::||||||||:||.||.|||||..|||.||.|||||.||||:..||:|||.|...:.|||:||
  Rat   232 ERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGVLRIFPEGKSFVADVEP 296

  Fly   368 KFDRLIFFWSDIRNPHEVQPAHRTRYAITVWYFDAKEREEALIRAKLENSKTNNLAAQAQAQQAE 432
            .||||:|||||.||||||||::.||||:|||||||:||.||       ..|..||..:.::..|:
  Rat   297 IFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEA-------KKKFRNLTRKTESALAK 354

Fly 433 432
Rat 355 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hph	NP_001287171.1	zf-MYND	30..67	CDD:280009
Hph	NP_001287171.1	P4Hc	220..400	CDD:214780	96/179 (54%)
Egln3	NP_062244.2	P4Hc	152..329	CDD:214780	98/185 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4245
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3432
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1604981at2759
OrthoFinder	1	1.000	-	-		FOG0001437
OrthoInspector	1	1.000	-	-		otm45737
orthoMCL	1	0.900	-	-		OOG6_104186
Panther	1	1.100	-	-	O	PTHR12907
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X899
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970