DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hph and EGLN1

DIOPT Version :9

Sequence 1:	NP_001287171.1	Gene:	Hph / 40633	FlyBaseID:	FBgn0264785	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_071334.1	Gene:	EGLN1 / 54583	HGNCID:	1232	Length:	426	Species:	Homo sapiens

Alignment Length:	418	Identity:	165/418 - (39%)
Similarity:	217/418 - (51%)	Gaps:	44/418 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GSHSASKSAMDPPRCSICGTQQQLLRCAKCKAVYYCSPAHQHLHWPDHRTECRLLTRQKLNSSNN 80
            |....|.|..|...|.:||..:.||||::|::.:||...||...|..|:..|: .:...|.....
Human     7 GPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQ-GSEGALGHGVG 70

  Fly    81 NKQQQ-----------RQQIQQLQQAVASA-NLECSGAGANCSTAQMMTPAHQAQSWPAEVDNLL 133
            ..|..           |...::.::|.|.. |.....|...........||..|....|..
Human    71 PHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAA---- 131

  Fly   134 NLLGQPGSQEKAAAAETETGQRQQQHQHHHHNGEKSSSYQIGLADASFMGSGSERRYEDLCR--- 195
                  |.|..|.|||.|.|:.:...:..... ||::.|.........:..|...|.....:
Human   132 ------GGQGSAVAAEAEPGKEEPPARSSLFQ-EKANLYPPSNTPGDALSPGGGLRPNGQTKPLP 189

  Fly   196 -------NIISDMNQYGLSVVDDFLGMETGLKILNEVRSMYNAGAFQDGQVVTNQTPDAPAVRGD 253
                   .|:..||::|:.|||||||.|||.:|.:|||::::.|.|.|||:|:.::..:     .
Human   190 ALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSS-----K 249

  Fly   254 KIRGDKIKWVGGNEPGCSNVWYLTNQIDSVVYRVNTMKDNGILGNYHIRERTRAMVACYPGSGTH 318
            .||||||.|:.|.||||..:..|.:.:|.::...     ||.||:|.|..||:||||||||:||.
Human   250 DIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHC-----NGKLGSYKINGRTKAMVACYPGNGTG 309

  Fly   319 YVMHVDNPQKDGRVITAIYYLNINWDARESGGILRIRPTPGTTVADIEPKFDRLIFFWSDIRNPH 383
            ||.|||||..|||.:|.|||||.:|||:.|||||||.|......||||||||||:|||||.||||
Human   310 YVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPH 374

  Fly   384 EVQPAHRTRYAITVWYFDAKEREEALIR 411
            |||||:.||||||||||||.||..|.::
Human   375 EVQPAYATRYAITVWYFDADERARAKVK 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hph	NP_001287171.1	zf-MYND	30..67	CDD:280009	14/36 (39%)
Hph	NP_001287171.1	P4Hc	220..400	CDD:214780	101/179 (56%)
EGLN1	NP_071334.1	Required for nuclear export	6..20		4/12 (33%)
		zf-MYND	21..58	CDD:280009	14/36 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..129		10/63 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..184		3/23 (13%)
		P4Hc	220..391	CDD:214780	101/180 (56%)
		Beta(2)beta(3) 'finger-like' loop. /evidence=ECO:0000269\|PubMed:18063574	241..251		1/14 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4350
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2931
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1604981at2759
OrthoFinder	1	1.000	-	-		FOG0001437
OrthoInspector	1	1.000	-	-		otm41615
orthoMCL	1	0.900	-	-		OOG6_104186
Panther	1	1.100	-	-	LDO	PTHR12907
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3122
SonicParanoid	1	1.000	-	-		X899
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.000