Protein Alignment Hph and Egln1

DIOPT Version :10

• Sequence 1: NP_730906.1
• Gene: Hph / 40633
• FlyBaseID: FBgn0264785
• Length: 478
• Species: Drosophila melanogaster
• Sequence 2: NP_444437.2
• Gene: Egln1 / 112405
• MGIID: 1932286
• Length: 400
• Species: Mus musculus
• Alignment Length: 422
• Identity: 165/422 - (39%)
• Similarity: 220/422 - (52%)
• Gaps: 66/422 - (15%)

  Fly    12 ASHSGSHSA-SKSAMDPPRCSICGTQQQLLRCAKCKAVYYCSPAHQHLHWPDHRTECRLLTRQKL 75
            ||.||.... |.|..|...|.:||..:.||||.:|::.:||...||...|..|:..|:
Mouse     2 ASDSGGPGVLSASERDRQYCELCGKMENLLRCGRCRSSFYCCKEHQRQDWKKHKLVCQ------- 59

  Fly    76 NSSNNNKQQQRQQIQQLQQAVASANLECSGA---------GANCSTAQMMTP--AHQAQSWPAEV 129
                 ..:..|.|....|..||.......||         |.:.:.:::..|  |.||:|.|..
Mouse    60 -----GGEAPRAQPAPAQPRVAPPPGGAPGAARAGGAARRGDSAAASRVPGPEDAAQARSGPGP- 118

  Fly   130 DNLLNLLGQPGSQEKAAAAETETGQRQQQHQHHHHNGEKSSSYQIGLADASFMGSGSERRYEDLC 194
                   .:|||::...:...              ..|::|....|......:..|...|.....
Mouse   119 -------AEPGSEDPPLSRSP--------------GPERASLCPAGGGPGEALSPGGGLRPNGQT 162

  Fly   195 R----------NIISDMNQYGLSVVDDFLGMETGLKILNEVRSMYNAGAFQDGQVVTNQTPDAPA 249
            :          .|:..||::|:.|||||||.|||.:|.:|||::::.|.|.|||:|:.::..:
Mouse   163 KPLPALKLALEYIVPCMNKHGICVVDDFLGRETGQQIGDEVRALHDTGKFTDGQLVSQKSDSS-- 225

  Fly   250 VRGDKIRGDKIKWVGGNEPGCSNVWYLTNQIDSVVYRVNTMKDNGILGNYHIRERTRAMVACYPG 314
               ..||||:|.|:.|.||||..:..|.:.:|.::...     :|.||||.|..||:||||||||
Mouse   226 ---KDIRGDQITWIEGKEPGCETIGLLMSSMDDLIRHC-----SGKLGNYRINGRTKAMVACYPG 282

  Fly   315 SGTHYVMHVDNPQKDGRVITAIYYLNINWDARESGGILRIRPTPGTTVADIEPKFDRLIFFWSDI 379
            :||.||.|||||..|||.:|.|||||.:|||:.|||||||.|......||||||||||:|||||.
Mouse   283 NGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDR 347

  Fly   380 RNPHEVQPAHRTRYAITVWYFDAKEREEALIR 411
            |||||||||:.||||||||||||.||..|.::
Mouse   348 RNPHEVQPAYATRYAITVWYFDADERARAKVK 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hph	NP_730906.1	zf-MYND	30..67	CDD:460312	14/36 (39%)
		P4Hc	220..400	CDD:214780	100/179 (56%)
Egln1	NP_444437.2	Required for nuclear export	6..20		4/13 (31%)
		zf-MYND	21..58	CDD:460312	14/36 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..161		22/120 (18%)
		PHA03247	<63..167	CDD:223021	22/125 (18%)
		P4Hc	192..368	CDD:214780	104/185 (56%)
		Beta(2)beta(3) 'finger-like' loop. /evidence=ECO:0000250|UniProtKB:Q9GZT9	218..228		1/14 (7%)