DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hph and EGLN2

DIOPT Version :9

Sequence 1:	NP_001287171.1	Gene:	Hph / 40633	FlyBaseID:	FBgn0264785	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_444274.1	Gene:	EGLN2 / 112398	HGNCID:	14660	Length:	407	Species:	Homo sapiens

Alignment Length:	349	Identity:	141/349 - (40%)
Similarity:	184/349 - (52%)	Gaps:	44/349 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LECSGAGA----NCS--TAQMMTPAHQAQSWPAEVDNLLNLLGQPGSQEKAAAAETETGQRQQQH 159
            |:..||.|    .|.  .||...|....:.|..:.       |...|..|...|       :|::
Human    91 LQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDG-------GDAPSPSKRPWA-------RQEN 141

  Fly   160 QHHHHNGEKSSSYQIGLADAS------FMGSGSERRYEDLCRNIISDMNQYGLSVVDDFLGMETG 218
            |.....|..|.|...|..:||      .:.|..||...|.   |:..|..||:.|.|.|||...|
Human   142 QEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDY---IVPCMRYYGICVKDSFLGAALG 203

  Fly   219 LKILNEVRSMYNAGAFQDGQVVTNQTPDAPAVRGDKIRGDKIKWVGGNEPGCSNVWYLTNQIDSV 283
            .::|.||.::...|..:|||:|:.:     |:....||||:|.||.|:||||.::..|...:|:|
Human   204 GRVLAEVEALKRGGRLRDGQLVSQR-----AIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAV 263

  Fly   284 VYRVNTMKDNGILGNYHIRERTRAMVACYPGSGTHYVMHVDNPQKDGRVITAIYYLNINWDARES 348
            :...     .|.||:|.|..||:||||||||:|..||.|||||..|||.||.|||||.|||.:..
Human   264 IRHC-----AGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVH 323

  Fly   349 GGILRIRPTPGTTVADIEPKFDRLIFFWSDIRNPHEVQPAHRTRYAITVWYFDAKEREEALIRAK 413
            ||:|:|.|.....||:|||.||||:.||||.||||||:||:.|||||||||||||||..|..:.:
Human   324 GGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQ 388

  Fly   414 LENSKTNNLAAQAQAQQAEPDSTT 437
            |.:.:..     .|...::|.:.|
Human   389 LASGQKG-----VQVPVSQPPTPT 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hph	NP_001287171.1	zf-MYND	30..67	CDD:280009
Hph	NP_001287171.1	P4Hc	220..400	CDD:214780	94/179 (53%)
EGLN2	NP_444274.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..89
		Bipartite nuclear localization signal. /evidence=ECO:0000269\|PubMed:19339211	89..134		11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..157		13/62 (21%)
		P4Hc	199..375	CDD:214780	96/185 (52%)
		Beta(2)beta(3) 'finger-like' loop. /evidence=ECO:0000250\|UniProtKB:Q9GZT9	225..235		2/14 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4350
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2931
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1604981at2759
OrthoFinder	1	1.000	-	-		FOG0001437
OrthoInspector	1	1.000	-	-		otm41615
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12907
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X899
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.070