DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12173 and UTR4

DIOPT Version :9

Sequence 1:	NP_649523.1	Gene:	CG12173 / 40630	FlyBaseID:	FBgn0037305	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_010876.2	Gene:	UTR4 / 856673	SGDID:	S000000764	Length:	227	Species:	Saccharomyces cerevisiae

Alignment Length:	242	Identity:	81/242 - (33%)
Similarity:	120/242 - (49%)	Gaps:	32/242 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVDIEGTTTSISFVHDVLFPYAKQNVEKFLRDSWEEDDIKRIVQDLQQVPQYADYKALLSGPPTE 76
            |:|||||...||||.:.||||....|.:.::....:..:..|:...     :.|.|..|.....|
Yeast     9 LLDIEGTVCPISFVKETLFPYFTNKVPQLVQQDTRDSPVSNILSQF-----HIDNKEQLQAHILE 68

  Fly    77 VDVDLIAGFVRYLIDQDLKVTPMKTLQGLIWAQGYANGELKGHVYEDVPAAFEAWRAAGLQIAVY 141
                        |:.:|:|...:|.|||.:||.||.:|::|..||.|.....:..:    ::.:|
Yeast    69 ------------LVAKDVKDPILKQLQGYVWAHGYESGQIKAPVYADAIDFIKRKK----RVFIY 117

  Fly   142 SSGSVAAQKLIFGHSLAGN--------LQPYLSAYFDTHV-GHKQEQQSYKNIAKQLKEDPKQIL 197
            |||||.||||:||:....|        |..|:..|||.:. |.|.|.|||.||.:.:.....::|
Yeast   118 SSGSVKAQKLLFGYVQDPNAPAHDSLDLNSYIDGYFDINTSGKKTETQSYANILRDIGAKASEVL 182

  Fly   198 FLTDIPGEAAAARCAGLQAIILKRPGNAALADDQKTGFELIPDFKPL 244
            ||:|.|.|..||...|:...:..|||||.:.|.||  :::..:|:.|
Yeast   183 FLSDNPLELDAAAGVGIATGLASRPGNAPVPDGQK--YQVYKNFETL 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12173	NP_649523.1	enolase-ppase	8..244	CDD:273760	80/240 (33%)
CG12173	NP_649523.1	HAD_2	11..217	CDD:290155	71/213 (33%)
UTR4	NP_010876.2	HAD_like	6..227	CDD:419670	80/240 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346068
Domainoid	1	1.000	105	1.000	Domainoid score	I1468
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I1307
Isobase	1	0.950	-	0	Normalized mean entropy	S1568
OMA	1	1.010	-	-		QHG62493
OrthoFinder	1	1.000	-	-		FOG0004317
OrthoInspector	1	1.000	-	-		oto99675
orthoMCL	1	0.900	-	-		OOG6_104759
Panther	1	1.100	-	-	LDO	PTHR20371
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R398
SonicParanoid	1	1.000	-	-		X3051
TreeFam	0	0.000	Not matched by this tool.
	13	12.880