DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and CTSF

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_003784.2	Gene:	CTSF / 8722	HGNCID:	2531	Length:	484	Species:	Homo sapiens

Alignment Length:	478	Identity:	170/478 - (35%)
Similarity:	238/478 - (49%)	Gaps:	99/478 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CTDPAVNSVAGDPAEKARLLNEKYVHRSRRSANDILGRH-------KPYDEEAAKAQLQKSLDKL 209
            |.||.|..:   |..|..||....|       .|.||||       .|.|.:...|...||  ..
Human    89 CNDPMVCRL---PVSKKTLLCSFQV-------LDELGRHVLLRKDCGPVDTKVPGAGEPKS--AF 141

  Fly   210 TAGEGPHYKIVKVYSASRQVDSGILTRIDADLIDGSEEQHRCIVDIWTKVWVRKDEHEITFKCRN 274
            |.|                  |.:::.:..:..|...|....::.:..:..:.:|
Human   142 TQG------------------SAMISSLSQNHPDNRNETFSSVISLLNEDPLSQD---------- 178

  Fly   275 QPVVQARHTRSVEWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTI 339
            .||                         |:..:|..|.:.:.|.|.|..|.:.||.:|..|:...
Human   179 LPV-------------------------KMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRA 218

  Fly   340 EELNANEMGSAKYGITEFADMTSSEYKE--RTGLWQRD------EAKATGGSAAVVPAYHGELPK 396
            :::.|.:.|:|:||:|:|:|:|..|::.  ...|.:::      :||:.|..|          |.
Human   219 QKIQALDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLA----------PP 273

  Fly   397 EFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLM 461
            |:|||.|.|||:||:||.||||||||||||:||.:.:..|.|...|||||||||..|.||.|||.
Human   274 EWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLP 338

  Fly   462 DNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISI 526
            .|||.|||::||||.|.:|.|:.....|:|:...:.|.:...|:|.: ||..:..||...||||:
Human   339 SNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQ-NEQKLAAWLAKRGPISV 402

  Fly   527 GINANAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYG-VSDYPNFHKTLPYWIVKNSWGPRWGEQ 590
            .|||..|||||.|:|.|.:.|||...:||.||:|||| .||       :|:|.:|||||..|||:
Human   403 AINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSD-------VPFWAIKNSWGTDWGEK 460

  Fly   591 GYYRVYRGDNTCGVSEMATSAVL 613
            |||.::||...|||:.||:|||:
Human   461 GYYYLHRGSGACGVNTMASSAVV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856	10/77 (13%)
		Inhibitor_I29	308..365	CDD:285458	19/56 (34%)
		Peptidase_C1A	395..611	CDD:239068	114/216 (53%)
CTSF	NP_003784.2	Inhibitor_I29	187..243	CDD:214853	19/55 (35%)
CTSF	NP_003784.2	Peptidase_C1	271..482	CDD:278538	116/228 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149680
Domainoid	1	1.000	238	1.000	Domainoid score	I2311
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2934
Isobase	1	0.950	-	0	Normalized mean entropy	S4265
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264766at2759
OrthoFinder	1	1.000	-	-		FOG0007524
OrthoInspector	1	1.000	-	-		oto90536
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	1	1.100	-	-	LDO	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.710