Protein Alignment CtsF and CTSF

DIOPT Version :10

• Sequence 1: NP_730901.1
• Gene: CtsF / 40628
• FlyBaseID: FBgn0260462
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_003784.2
• Gene: CTSF / 8722
• HGNCID: 2531
• Length: 484
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 170/478 - (35%)
• Similarity: 238/478 - (49%)
• Gaps: 99/478 - (20%)

  Fly   152 CTDPAVNSVAGDPAEKARLLNEKYVHRSRRSANDILGRH-------KPYDEEAAKAQLQKSLDKL 209
            |.||.|..:   |..|..||....|       .|.||||       .|.|.:...|...||  ..
Human    89 CNDPMVCRL---PVSKKTLLCSFQV-------LDELGRHVLLRKDCGPVDTKVPGAGEPKS--AF 141

  Fly   210 TAGEGPHYKIVKVYSASRQVDSGILTRIDADLIDGSEEQHRCIVDIWTKVWVRKDEHEITFKCRN 274
            |.|                  |.:::.:..:..|...|....::.:..:..:.:|
Human   142 TQG------------------SAMISSLSQNHPDNRNETFSSVISLLNEDPLSQD---------- 178

  Fly   275 QPVVQARHTRSVEWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTI 339
            .||                         |:..:|..|.:.:.|.|.|..|.:.||.:|..|:...
Human   179 LPV-------------------------KMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRA 218

  Fly   340 EELNANEMGSAKYGITEFADMTSSEYKE--RTGLWQRD------EAKATGGSAAVVPAYHGELPK 396
            :::.|.:.|:|:||:|:|:|:|..|::.  ...|.:::      :||:.|..|          |.
Human   219 QKIQALDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLA----------PP 273

  Fly   397 EFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLM 461
            |:|||.|.|||:||:||.||||||||||||:||.:.:..|.|...|||||||||..|.||.|||.
Human   274 EWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLP 338

  Fly   462 DNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISI 526
            .|||.|||::||||.|.:|.|:.....|:|:...:.|.:...|:|.: ||..:..||...||||:
Human   339 SNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQ-NEQKLAAWLAKRGPISV 402

  Fly   527 GINANAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYG-VSDYPNFHKTLPYWIVKNSWGPRWGEQ 590
            .|||..|||||.|:|.|.:.|||...:||.||:|||| .||       :|:|.:|||||..|||:
Human   403 AINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSD-------VPFWAIKNSWGTDWGEK 460

  Fly   591 GYYRVYRGDNTCGVSEMATSAVL 613
            |||.::||...|||:.||:|||:
Human   461 GYYYLHRGSGACGVNTMASSAVV 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsF	NP_730901.1	Inhibitor_I29	308..365	CDD:462410	19/56 (34%)
		Peptidase_C1A	395..611	CDD:239068	114/216 (53%)
CTSF	NP_003784.2	Inhibitor_I29	187..243	CDD:214853	19/55 (35%)
		Peptidase_C1	271..482	CDD:425470	116/228 (51%)