DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctsw

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001039033.1	Gene:	ctsw / 733785	XenbaseID:	XB-GENE-963153	Length:	303	Species:	Xenopus tropicalis

Alignment Length:	314	Identity:	103/314 - (32%)
Similarity:	167/314 - (53%)	Gaps:	39/314 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 VRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGITEFADMTSSE---YKERTG---- 370
            :::.|.|.:..|.:.|||||.:|||....|...|:|:|:||:|:|:|:|..|   |...|.
Frog     2 LQYNRSYKTREEFKYRLRIFSENLKEASRLQREELGTAQYGVTKFSDLTDEEFSIYHLPTNILPT 66

  Fly   371 ---LWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYA 432
               |.|.:|         |:|     .|...|||.::.:::.|||.:|.|||||:...|||..:|
Frog    67 PPILKQSEE---------VLP-----FPTSCDWRTQNVISKAKNQRTCHSCWAFAAVANIEAQWA 117

  Fly   433 VKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSH 497
            : .|:....|||:::||:|..:.|:||...:|:..:...|||..|..|||....:.|.     ..
Frog   118 I-LGQTISLSEQQVIDCNTCRNGCSGGYAWDAFMTVLQQGGLTSEKSYPYTGHVSNCR-----KG 176

  Fly   498 VQVAGFV---DLPKGNETAMQEWLLANGPISIGINANAMQFYRGGVSHPWKALCSKKNLDHGVLV 559
            .:..|::   ::.|.|||||...:...|.:::.||...::.|:.|:....::.|....:||.||:
Frog   177 FEAVGWIHDFEMLKKNETAMASHVAHKGTLTVTINKAPLKHYQKGIVDTLRSNCDPNYVDHVVLI 241

  Fly   560 VGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSAVL 613
            |||....      .||.||:|||||..|||:|::|::|..|.||:::...:.::
Frog   242 VGYRGGG------KLPQWILKNSWGEDWGEKGFFRMFRDKNACGITKYPVTCIV 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	22/54 (41%)
		Peptidase_C1A	395..611	CDD:239068	74/218 (34%)
ctsw	NP_001039033.1	Inhibitor_I29	1..53	CDD:214853	21/50 (42%)
ctsw	NP_001039033.1	Peptidase_C1A	80..285	CDD:239068	74/216 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020