DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Cts8

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001121688.1	Gene:	Cts8 / 680718	RGDID:	1588248	Length:	333	Species:	Rattus norvegicus

Alignment Length:	329	Identity:	114/329 - (34%)
Similarity:	166/329 - (50%)	Gaps:	41/329 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 EWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAK 351
            ||.|.||                    ::.:.|....|.|.| .::.:|:|.:::.|. |....|
  Rat    28 EWQEWKT--------------------KYEKNYSLEEEGQKR-AVWEENMKVVKQHNI-EYDQEK 70

  Fly   352 YGIT----EFADMTSSEY-KERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKN 411
            ...|    .|||||..|: |..|.:..::..|    ..::.......|||..|||::..||.|||
  Rat    71 KNFTMELNAFADMTGEEFRKMMTNIPVQNLRK----KKSIHQPIFRYLPKFVDWRRRGYVTSVKN 131

  Fly   412 QGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDS--ACNGGLMDNAYKAIKDIGGL 474
            ||:|.|||||||.|.|||....|||.|...|.|.|:||...:.  .|:.|....|.|.:...|||
  Rat   132 QGTCNSCWAFSVAGAIEGQMFRKTGRLVSLSPQNLVDCSRPEGNHGCHMGSTLYALKYVWSNGGL 196

  Fly   475 EYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINAN--AMQFYR 537
            |.|:.|||:.|:..|.:....|..:|.||..:.: :|.|:...:...||||:||:|:  :.:|||
  Rat   197 EAESTYPYEGKEGPCRYLPRRSAARVTGFSTVAR-SEEALMHAVATIGPISVGIDASHVSFRFYR 260

  Fly   538 GGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNT 601
            .|:.  ::..||...::|.|||||||.....:..:  .||::|||.|..||..||.::.|| :|.
  Rat   261 RGIY--YEPRCSSNRINHSVLVVGYGYEGRESDGR--KYWLIKNSHGVGWGMNGYMKLARGWNNH 321

  Fly   602 CGVS 605
            ||::
  Rat   322 CGIA 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	15/60 (25%)
		Peptidase_C1A	395..611	CDD:239068	89/216 (41%)
Cts8	NP_001121688.1	PTZ00203	5..327	CDD:185513	114/329 (35%)
		Inhibitor_I29	29..87	CDD:214853	19/79 (24%)
		Peptidase_C1A	115..331	CDD:239068	89/216 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810