DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsb

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_072119.2	Gene:	Ctsb / 64529	RGDID:	621509	Length:	339	Species:	Rattus norvegicus

Alignment Length:	264	Identity:	69/264 - (26%)
Similarity:	106/264 - (40%)	Gaps:	59/264 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 LPKEFD----WRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKT-GELK-EFSEQELLDC--D 450
            ||:.||    |.....:.|:::||||||||||.....:.....:.| |.:. |.|.::||.|  .
  Rat    80 LPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGI 144

  Fly   451 TTDSACNGGLMDNAY-----KAIKDIGGLEYEAE---YPYKAKKNQCHFNRTLSHVQVAGFVDLP 507
            .....||||....|:     |.:  :.|..|.:.   .||.....:.|.|.  |.....|..|.|
  Rat   145 QCGDGCNGGYPSGAWNFWTRKGL--VSGGVYNSHIGCLPYTIPPCEHHVNG--SRPPCTGEGDTP 205

  Fly   508 KGN---------------------------ETAMQEWLLANGPISIGINANAMQF--YRGGVSHP 543
            |.|                           |..:...:..|||:. |.......|  |:.||
  Rat   206 KCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVE-GAFTVFSDFLTYKSGV--- 266

  Fly   544 WKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMA 608
            :|.........|.:.::|:|:.:      .:|||:|.|||...||:.|::::.||:|.||:....
  Rat   267 YKHEAGDVMGGHAIRILGWGIEN------GVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEI 325

  Fly   609 TSAV 612
            .:.:
  Rat   326 VAGI 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458
		Peptidase_C1A	395..611	CDD:239068	68/260 (26%)
Ctsb	NP_072119.2	Propeptide_C1	26..65	CDD:285358
Ctsb	NP_072119.2	Peptidase_C1A_CathepsinB	81..328	CDD:239111	68/260 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810