DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsm

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001347650.1	Gene:	Ctsm / 64139	MGIID:	1927229	Length:	333	Species:	Mus musculus

Alignment Length:	316	Identity:	110/316 - (34%)
Similarity:	167/316 - (52%)	Gaps:	23/316 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 VDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGIT----EFADMTSSE 364
            :|..:.|:::::|:.|....|.|.| .::..|:|.| :|:..|.|..|:|.|    .|.|||..|
Mouse    25 LDVEWQKWKIKYGKAYSLEEEGQKR-AVWEDNMKKI-KLHNGENGLGKHGFTMEMNAFGDMTLEE 87

  Fly   365 YKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEG 429
            :::   :.............:|.......|||..:|:::..||.|:.||.|.|||||||||.|||
Mouse    88 FRK---VMIEIPVPTVKKGKSVQKRLSVNLPKFINWKKRGYVTPVQTQGRCNSCWAFSVTGAIEG 149

  Fly   430 LYAVKTGELKEFSEQELLDCDTTDSACNGG-LMDNAYKA---IKDIGGLEYEAEYPYKAKKNQCH 490
            ....|||:|...|.|.|:||.....  |.| .:.|.|.|   :.:.||||.||.|||:.|...|.
Mouse   150 QMFRKTGQLIPLSVQNLVDCSRPQG--NWGCYLGNTYLALHYVMENGGLESEATYPYEEKDGSCR 212

  Fly   491 FNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINAN--AMQFYRGGVSHPWKALCSKKNL 553
            ::...|...:.||..:|| ||.|:...:.:.||||:.|:|.  :..||:.|:.  ::..||...:
Mouse   213 YSPENSTANITGFEFVPK-NEDALMNAVASIGPISVAIDARHASFLFYKRGIY--YEPNCSSSVV 274

  Fly   554 DHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVSEMA 608
            .|.:|:||||.:...:..:  .||:||||.|.:||.:||.::.|. .|.||::..|
Mouse   275 THSMLLVGYGFTGRESDGR--KYWLVKNSMGTQWGNKGYMKISRDKGNHCGIATYA 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	19/60 (32%)
		Peptidase_C1A	395..611	CDD:239068	87/221 (39%)
Ctsm	NP_001347650.1	Inhibitor_I29	29..87	CDD:214853	19/59 (32%)
Ctsm	NP_001347650.1	Peptidase_C1A	115..331	CDD:239068	87/221 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810