DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsz

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_071720.1	Gene:	Ctsz / 64138	MGIID:	1891190	Length:	306	Species:	Mus musculus

Alignment Length:	238	Identity:	82/238 - (34%)
Similarity:	112/238 - (47%)	Gaps:	47/238 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 ELPKEFDWRQKDAV---TQVKNQ---GSCGSCWAFSVTGNIEGLYAVK-TGELKE--FSEQELLD 448
            :|||.:|||..:.|   :..:||   ..||||||...|..:.....:| .|....  .|.|.::|
Mouse    63 DLPKNWDWRNVNGVNYASVTRNQHIPQYCGSCWAHGSTSAMADRINIKRKGAWPSILLSVQNVID 127

  Fly   449 CDTTDSACNGG----LMDNAYK-AIKDIGGLEYEAEYPYKAKKNQ---------CHF--NRTLSH 497
            |....| |.||    :.:.|:| .|.|.....|:|:.....|.||         ||.  |.||..
Mouse   128 CGNAGS-CEGGNDLPVWEYAHKHGIPDETCNNYQAKDQDCDKFNQCGTCTEFKECHTIQNYTLWR 191

  Fly   498 VQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQF-YRGGV--SHPWKALCSKKNLDHGVLV 559
            |...|.:   .|.|..|.| :.||||||.||.|..|.. |.||:  .|..:|:     ::|.:.|
Mouse   192 VGDYGSL---SGREKMMAE-IYANGPISCGIMATEMMSNYTGGIYAEHQDQAV-----INHIISV 247

  Fly   560 VGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRV----YRG 598
            .|:|||     :..:.||||:||||..|||:|:.|:    |:|
Mouse   248 AGWGVS-----NDGIEYWIVRNSWGEPWGEKGWMRIVTSTYKG 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458
		Peptidase_C1A	395..611	CDD:239068	81/236 (34%)
Ctsz	NP_071720.1	Peptidase_C1A_CathepsinX	64..305	CDD:239149	82/237 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900