DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsr

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_064680.1	Gene:	Ctsr / 56835	MGIID:	1861723	Length:	334	Species:	Mus musculus

Alignment Length:	323	Identity:	115/323 - (35%)
Similarity:	172/323 - (53%)	Gaps:	36/323 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 VDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGIT----EFADMTSSE 364
            :|..:..:::::.:.| |..|.:::..::.:.||.| :|:..|....|.|.|    ||.|.|..|
Mouse    25 LDAEWQDWKIKYNKSY-SLKEEKLKRVVWEEKLKMI-KLHNRENSLGKNGFTMKMNEFGDQTDEE 87

  Fly   365 YKE---RTGLWQRDEAKA----TGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFS 422
            :::   ...:|...|.|:    ..||.         |||..|||:|..||.|:.||.|.:||||:
Mouse    88 FRKMMIEISVWTHREGKSIMKREAGSI---------LPKFVDWRKKGYVTPVRRQGDCDACWAFA 143

  Fly   423 VTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAK 485
            |||.||.....:||:|...|.|.|:||...  ::.|.||...||::.:...||||.||.|||:.|
Mouse   144 VTGAIEAQAIWQTGKLTPLSVQNLVDCSKPQGNNGCLGGDTYNAFQYVLHNGGLESEATYPYEGK 208

  Fly   486 KNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQF--YRGGVSHPWKALC 548
            ...|.:|...|..::.|||.||:..:..|.. :...|||:.||:|:...|  |:||:.|  :..|
Mouse   209 DGPCRYNPKNSKAEITGFVSLPQSEDILMAA-VATIGPITAGIDASHESFKNYKGGIYH--EPNC 270

  Fly   549 SKKNLDHGVLVVGYGVS--DYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVSEMA 608
            |...:.|||||||||..  :....|    ||::|||||.|||.:||.::.:. :|.||::..|
Mouse   271 SSDTVTHGVLVVGYGFKGIETDGNH----YWLIKNSWGKRWGIRGYMKLAKDKNNHCGIASYA 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	15/60 (25%)
		Peptidase_C1A	395..611	CDD:239068	92/221 (42%)
Ctsr	NP_064680.1	PTZ00203	15..332	CDD:185513	115/323 (36%)
		Inhibitor_I29	29..87	CDD:214853	15/59 (25%)
		Peptidase_C1A	116..332	CDD:239068	92/221 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810