DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and cts12

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_021329137.1	Gene:	cts12 / 567046	ZFINID:	ZDB-GENE-050208-336	Length:	349	Species:	Danio rerio

Alignment Length:	376	Identity:	121/376 - (32%)
Similarity:	178/376 - (47%)	Gaps:	66/376 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 IWTKVWVRKDEHEITFKCRNQPVVQARHTRSVEWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRY 319
            :|..|.|..:..|               ....||...|  |||...:|:
Zfish    23 VWAPVQVASESEE---------------EAPTEWNLWK--KKHEISYDE---------------- 54

  Fly   320 VSTAERQMRLRIFRQNLKTIEELNANE----MGSAKYGITEFADMTSSEYKERTGLWQRDEAKAT 380
              .:|...|..|:..|::.|.: |.|:    :...|..:.::.|:||.|||...|    .:.|.|
Zfish    55 --ESEDVHRKTIWETNMQKIWK-NNNDFSFGLSMFKMAMNKYGDLTSVEYKRLLG----SKIKGT 112

  Fly   381 GG------SAAVVPAYHGEL-PKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGEL 438
            |.      ||.::......| ....|:|.|..||:||:||.|||||:||.||.|||.....||.|
Zfish   113 GNRKGKITSAQMLRLNAKRLGVTNIDYRAKGYVTEVKDQGYCGSCWSFSTTGAIEGQMYKHTGRL 177

  Fly   439 KEFSEQELLDCDTT--DSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQ-CHFNRTLSHVQV 500
            ...|||:|:||..:  ...|:|..|.|||..:.: ..||....|||.:...| |.:.:.|:...:
Zfish   178 VSLSEQQLVDCSRSYGTYGCSGAWMANAYDYVIN-NALESSDTYPYTSVDTQPCFYEKNLAMAGI 241

  Fly   501 AGFVDLPKGNETAMQEWLLANGPISIGINAN--AMQFYRGGVSHPWKALCSKKNLDHGVLVVGYG 563
            :.:..:|.|||.|:.:.:...||:|:.|:|:  :..||..|:..  ::.|:..||:|.|||||||
Zfish   242 SDYRFVPAGNEQALADAVATVGPVSVAIDADNPSFLFYSSGIYK--ESNCNPNNLNHAVLVVGYG 304

  Fly   564 VSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYR-GDNTCGVSEMATSAVL 613
            ..:..:      |||:|||||..|||.||.|:.| |.||||::..|...::
Zfish   305 SEEGTD------YWIIKNSWGTGWGEGGYMRMIRNGKNTCGIASYALYPII 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856	4/16 (25%)
		Inhibitor_I29	308..365	CDD:285458	11/60 (18%)
		Peptidase_C1A	395..611	CDD:239068	89/221 (40%)
cts12	XP_021329137.1	Inhibitor_I29	41..101	CDD:311939	17/80 (21%)
cts12	XP_021329137.1	Peptidase_C1A	135..347	CDD:239068	89/220 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810