Protein Alignment CG12163 and Ctsf

DIOPT Version :9

• Sequence 1: NP_730901.1
• Gene: CG12163 / 40628
• FlyBaseID: FBgn0260462
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_063914.1
• Gene: Ctsf / 56464
• MGIID: 1861434
• Length: 462
• Species: Mus musculus
• Alignment Length: 534
• Identity: 177/534 - (33%)
• Similarity: 251/534 - (47%)
• Gaps: 110/534 - (20%)

  Fly   108 LLNALDTKAIQPAEADIVCRLVILEKPWLRTQ--WGDKHRELVTSNCTDPAVNSVAGDPAEKARL 170
            ||..|.|.|:.|..|          |||...:  |....:||:.                 .||.
Mouse    10 LLTLLSTVALSPVPA----------KPWADDEQAWNLSSQELLA-----------------PARF 47

  Fly   171 LNEKYVHRSRRSANDILGRHKPYDEEAAKAQLQKSLDKLTAGEG--------------------- 214
            ..:.|.:........:||        |.:.::::      ||:|
Mouse    48 ALDMYNYGRAAGTRAVLG--------AVRGRVRR------AGQGSLFSLEATLEEPPCNDPLVCP 98

  Fly   215 -PHYK--IVKVYSASRQVDSGILTRIDADLIDGSEEQHRCIVDIWTKVWVRKDEHEITFKCRNQP 276
             |..|  ::..:....::...:|.|.|...::....:.|..........:.||.....|..:..|
Mouse    99 LPETKKTVLCSFEVLEELKEHLLLRRDCSPVNAKVTEFRNATFSSFLPLLDKDPLPQDFSVKMAP 163

  Fly   277 VVQARHTRSVEWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEE 341
                                          ||..|...:.|.|.|..|.|.||.:|.:|:...::
Mouse   164 ------------------------------LFKDFMTTYNRTYESREEAQWRLTVFARNMIRAQK 198

  Fly   342 LNANEMGSAKYGITEFADMTSSEYKE--RTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKD 404
            :.|.:.|:|:||||:|:|:|..|:..  ...|.|    |.:|...:...:.:...|.|:|||:|.
Mouse   199 IQALDRGTAQYGITKFSDLTEEEFHTIYLNPLLQ----KESGRKMSPAKSINDLAPPEWDWRKKG 259

  Fly   405 AVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIK 469
            |||:|||||.||||||||||||:||.:.:..|.|...|||||||||..|.||.|||..|||.|||
Mouse   260 AVTEVKNQGMCGSCWAFSVTGNVEGQWFLNRGTLLSLSEQELLDCDKVDKACLGGLPSNAYAAIK 324

  Fly   470 DIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQ 534
            ::||||.|.:|.|:.....|:|:..::.|.:...|:|.: ||..:..||...||||:.|||..||
Mouse   325 NLGGLETEDDYGYQGHVQTCNFSAQMAKVYINDSVELSR-NENKIAAWLAQKGPISVAINAFGMQ 388

  Fly   535 FYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGD 599
            |||.|::||::.|||...:||.||:||||      ....:|||.:|||||..|||:|||.:|||.
Mouse   389 FYRHGIAHPFRPLCSPWFIDHAVLLVGYG------NRSNIPYWAIKNSWGSDWGEEGYYYLYRGS 447

  Fly   600 NTCGVSEMATSAVL 613
            ..|||:.||:|||:
Mouse   448 GACGVNTMASSAVV 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856	13/101 (13%)
		Inhibitor_I29	308..365	CDD:285458	21/56 (38%)
		Peptidase_C1A	395..611	CDD:239068	115/215 (53%)
Ctsf	NP_063914.1	Inhibitor_I29	165..221	CDD:214853	21/55 (38%)
		Peptidase_C1	249..460	CDD:278538	116/217 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839735
Domainoid	1	1.000	249	1.000	Domainoid score	I2125
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2779
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007524
OrthoInspector	1	1.000	-	-		oto94125
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	1	1.100	-	-	LDO	PTHR12411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3471
SonicParanoid	1	1.000	-	-		X3186
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780