DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Cts8

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_062414.3	Gene:	Cts8 / 56094	MGIID:	1860275	Length:	333	Species:	Mus musculus

Alignment Length:	327	Identity:	108/327 - (33%)
Similarity:	158/327 - (48%)	Gaps:	45/327 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 VDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNAN-EMGSAKY--GITEFADMTSSEY 365
            :|..:.:::.:|.:.|....|.|.| .::.:|:|.:::.|.. :.|...:  .:..|.|||..||
Mouse    25 LDSEWQEWKRKFNKNYSMEEEGQKR-AVWEENMKLVKQHNIEYDQGKKNFTMDVNAFGDMTGEEY 88

  Fly   366 KERTGLWQRDEAKATGGSAAVVPAYH----------GELPKEFDWRQKDAVTQVKNQGSCGSCWA 420
            ::..             :...||.:.          |.|||..|||::..||.|||||:|.||||
Mouse    89 RKML-------------TDIPVPNFRKKKSIHQPIAGYLPKFVDWRKRGCVTPVKNQGTCNSCWA 140

  Fly   421 FSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDS--ACNGGLMDNAYKAIKDIGGLEYEAEYPYK 483
            ||..|.|||....|||:|...|.|.|:||...:.  .|..|....|.|.:....|||.|:.||||
Mouse   141 FSAAGAIEGQMFRKTGKLVPLSTQNLVDCSRLEGNFGCFKGSTFLALKYVWKNRGLEAESTYPYK 205

  Fly   484 AKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQF--YRGGVSHPWKA 546
            .....|.::...|..::..| .....:|..:...:...||||:||:|....|  ||.|:.:..|
Mouse   206 GTDGHCRYHPERSAARITSF-SFVSNSEKDLMRAVATIGPISVGIDARHKSFRLYREGIYYEPK- 268

  Fly   547 LCSKKNLDHGVLVVGYGV----SDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVSE 606
             ||...::|.|||||||.    ||...      ||::|||.|.:||..||.::.|| :|.||::.
Mouse   269 -CSSNIINHSVLVVGYGYEGKESDGNK------YWLIKNSHGEQWGMNGYMKLARGRNNHCGIAS 326

  Fly   607 MA 608
            .|
Mouse   327 YA 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	13/59 (22%)
		Peptidase_C1A	395..611	CDD:239068	88/223 (39%)
Cts8	NP_062414.3	Inhibitor_I29	29..87	CDD:214853	13/58 (22%)
Cts8	NP_062414.3	Peptidase_C1A	115..331	CDD:239068	88/223 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810