DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Cts7

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001346316.1	Gene:	Cts7 / 56092	MGIID:	1860262	Length:	331	Species:	Mus musculus

Alignment Length:	338	Identity:	121/338 - (35%)
Similarity:	173/338 - (51%)	Gaps:	55/338 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 EWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEE---LNANEMG 348
            ||.|.|                     |...|..|..|.:.|..::..|:|.|::   .|...|.
Mouse    28 EWEEWK---------------------RSNDRTYSPEEEKQRRAVWEGNVKWIKQHIMENGLWMN 71

  Fly   349 SAKYGITEFADMTSSEYKERTGLWQRDEAKATGGSAAVVPAYHG--------ELPKEFDWRQKDA 405
            :....:.||.|||..|.|..|             .::..|..:|        ::|...|||::..
Mouse    72 NFTIEMNEFGDMTGEEMKMLT-------------ESSSYPLRNGKHIQKRNPKIPPTLDWRKEGY 123

  Fly   406 VTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAI 468
            ||.|:.|||||:|||||||..|||....|||:|...|.|.|:||..:  ...|:||...:|::.:
Mouse   124 VTPVRRQGSCGACWAFSVTACIEGQLFKKTGKLIPLSVQNLMDCSVSYGTKGCDGGRPYDAFQYV 188

  Fly   469 KDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAM 533
            |:.||||.||.|||:||...|.:....|.|:|..|..:|: ||.|:.:.|:.:|||::.|:.:..
Mouse   189 KNNGGLEAEATYPYEAKAKHCRYRPERSVVKVNRFFVVPR-NEEALLQALVTHGPIAVAIDGSHA 252

  Fly   534 QF--YRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVY 596
            .|  ||||:.|..|  |.|..||||:|:||||...:.:.::  .||::|||.|.||||.||.::.
Mouse   253 SFHSYRGGIYHEPK--CRKDTLDHGLLLVGYGYEGHESENR--KYWLLKNSHGERWGENGYMKLP 313

  Fly   597 RGDNT-CGVSEMA 608
            ||.|. ||::..|
Mouse   314 RGQNNYCGIASYA 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	15/59 (25%)
		Peptidase_C1A	395..611	CDD:239068	97/219 (44%)
Cts7	NP_001346316.1	Inhibitor_I29	29..87	CDD:214853	18/78 (23%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18776147	33..50		6/37 (16%)
		Peptidase_C1A	113..329	CDD:239068	97/219 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710