DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctsk

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001017778.1	Gene:	ctsk / 550475	ZFINID:	ZDB-GENE-001205-4	Length:	333	Species:	Danio rerio

Alignment Length:	329	Identity:	121/329 - (36%)
Similarity:	178/329 - (54%)	Gaps:	26/329 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 SHRFD--KVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNAN-EMGSAKY--GITEF 357
            :|..|  .:|..:..:::...|.|....|..:|..|:.:|:..||..|.. |:|...|  |:..|
Zfish    18 AHSLDNLSLDEAWESWKITHKREYNGLNEESIRRTIWEKNMLFIEAHNKEYELGIHTYDLGMNHF 82

  Fly   358 ADMTSSEYKERT-GL---WQRDEAKATGGSAAVVPAYH-GELPKEFDWRQKDAVTQVKNQGSCGS 417
            .|||..|..|:. ||   ..||.|.      ..||... |:|||..|:|:...||.|||||||||
Zfish    83 GDMTLEEVAEKVMGLQMPMYRDPAN------TFVPDDRVGKLPKSIDYRKLGYVTSVKNQGSCGS 141

  Fly   418 CWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPY 482
            |||||..|.:||......|:|.:.|.|.|:||.|.:..|.||.|.||::.:.:..|::.|..|||
Zfish   142 CWAFSSVGALEGQLMKTKGQLVDLSPQNLVDCVTENDGCGGGYMTNAFRYVSNNQGIDSEESYPY 206

  Fly   483 KAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINA--NAMQFYRGGVSHPWK 545
            .....||.:|.:.......|:.::|:|||.|:...:...||:|:||:|  :...:|:.||.  :.
Zfish   207 VGTDQQCAYNTSGVAASCRGYKEIPQGNERALTAAVANVGPVSVGIDAMQSTFLYYKSGVY--YD 269

  Fly   546 ALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVSEMAT 609
            ..|:|::::|.||.||||.:  |...|   |||||||||..||::||..:.|. :|.||::.:|:
Zfish   270 PNCNKEDVNHAVLAVGYGAT--PRGKK---YWIVKNSWGEEWGKKGYVLMARNRNNACGIANLAS 329

  Fly   610 SAVL 613
            ..|:
Zfish   330 FPVM 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	17/59 (29%)
		Peptidase_C1A	395..611	CDD:239068	89/218 (41%)
ctsk	NP_001017778.1	Inhibitor_I29	30..89	CDD:214853	17/58 (29%)
ctsk	NP_001017778.1	Peptidase_C1	118..332	CDD:278538	90/220 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710