DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctsz

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001006043.1	Gene:	ctsz / 450022	ZFINID:	ZDB-GENE-041010-139	Length:	301	Species:	Danio rerio

Alignment Length:	245	Identity:	76/245 - (31%)
Similarity:	108/245 - (44%)	Gaps:	61/245 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 ELPKEFDWRQKDAVTQV---KNQ---GSCGSCWAFSVTG------NIEGLYAVKTGELKEFSEQE 445
            |||||:|||....|..|   :||   ..||||||...|.      ||:...|..:..|   |.|.
Zfish    53 ELPKEWDWRNIKGVNYVSTTRNQHIPQYCGSCWAHGSTSALADRINIKRKAAWPSAYL---SVQN 114

  Fly   446 LLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQCH-FNR--TLSHVQVAGFVDLP 507
            ::||....| |:||.....::...: .|:..|....|:||...|. ||:  |.:...|...|.
Zfish   115 VIDCGDAGS-CSGGDHSGVWEYAHN-KGIPDETCNNYQAKDQDCKPFNQCGTCTTFGVCNIVK-- 175

  Fly   508 KGNET--------------AMQEWLLANGPISIGINA-NAMQFYRGG-----VSHPWKALCSKKN 552
              |.|              .|:..:.:.||||.||.| :.:..|.||     |..|:
Zfish   176 --NFTLWKVGDYGSASGLDKMKAEIYSGGPISCGIMATDKLDAYTGGLYSEYVQEPY-------- 230

  Fly   553 LDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRV----YRG 598
            ::|.|.|.|:||.:     ..:.:|:|:||||..|||:|:.|:    |:|
Zfish   231 INHIVSVAGWGVDE-----NGVEFWVVRNSWGEPWGEKGWLRIVTSAYKG 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458
		Peptidase_C1A	395..611	CDD:239068	74/243 (30%)
ctsz	NP_001006043.1	Peptidase_C1A_CathepsinX	54..295	CDD:239149	75/244 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900