DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctsl.1

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001002368.1	Gene:	ctsl.1 / 436641	ZFINID:	ZDB-GENE-040718-61	Length:	334	Species:	Danio rerio

Alignment Length:	323	Identity:	130/323 - (40%)
Similarity:	185/323 - (57%)	Gaps:	33/323 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 DHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLK--TIEELNANE-MGSAKYGITEFADMTSSEYK 366
            |..|:.::::||:.|.|..|...|...:..|.|  .:..:.|:: :.|.:.|:|.||||::.||:
Zfish    23 DMEFHAWKLKFGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYR 87

  Fly   367 E---RTGLWQRDEAKATGGS-------AAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAF 421
            :   |..|...:..||.|||       ||||       |...|||.|..||.:|:|..|||||||
Zfish    88 QLVFRGCLGSMNNTKARGGSTFFRLRKAAVV-------PDTVDWRDKGYVTDIKDQKQCGSCWAF 145

  Fly   422 SVTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAIKDIGGLEYEAEYPYKA 484
            |.||::||....|||:|...|||:|:||..:  :..|:|||||.|::.|:...||:.|..|||:|
Zfish   146 SATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEA 210

  Fly   485 KKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINA--NAMQFYRGGVSHPWKAL 547
            :..:|.||.:.......|:||:..|:|:|:||.:...||||:.|:|  ::.|.|..||.:  :..
Zfish   211 QDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYN--EPD 273

  Fly   548 CSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVSEMAT 609
            ||...||||||.||||.|:..:      |||||||||..||.|||..:.|. .|.||::..|:
Zfish   274 CSSSELDHGVLAVGYGSSNGDD------YWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAAS 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	17/59 (29%)
		Peptidase_C1A	395..611	CDD:239068	99/220 (45%)
ctsl.1	NP_001002368.1	Inhibitor_I29	26..86	CDD:285458	17/59 (29%)
ctsl.1	NP_001002368.1	Peptidase_C1	118..333	CDD:278538	100/228 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710