DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctsc

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_012812143.2	Gene:	ctsc / 407938	XenbaseID:	XB-GENE-940480	Length:	458	Species:	Xenopus tropicalis

Alignment Length:	315	Identity:	101/315 - (32%)
Similarity:	148/315 - (46%)	Gaps:	57/315 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 RIFRQNLKTIEELNANEMGSAKYGITEFADMTSSEYKERTGLWQRDEAKATGGSAAVVP------ 388
            |::..|...::::|..:           ...|::.|.|..|:...|..:..||..:.:|
Frog   162 RLYNYNHDFVKQINEVQ-----------KSWTATAYPEYEGMTIEDLIRRAGGRNSRIPMRPRPA 215

  Fly   389 ------AYHGELPKEFDWRQ---KDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKE---F 441
                  .|.| ||.|:|||.   .:.||.|:||.|||||:|||..|.:|....::: :|.:   .
Frog   216 PLPTDEKYQG-LPTEWDWRNIAGYNFVTPVRNQASCGSCYAFSSMGMLESRIQIRS-QLSQKPIL 278

  Fly   442 SEQELLDCDTTDSACNGG---LMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFN------RTLSH 497
            |.|:::.|......|.||   |:  |.|.:.|.|.:| |::.||....:.|...      .|..:
Frog   279 SPQQVVSCSNYSQGCEGGFPYLI--AGKYVSDYGIVE-ESDLPYTGSDSPCTLKDSQQKYYTAEY 340

  Fly   498 VQVAGFVDLPKG-NETAMQEWLLANGPISIGINA-NAMQFYRGGVSHPWKALCSKKN----LDHG 556
            ..|.||..   | ||..|:..|:..||:|:.... :....||.||.| ...|..|.|    .:|.
Frog   341 HYVGGFYG---GCNEAYMKLELVLGGPLSVAFEVYDDFMHYRSGVYH-HTGLQDKFNPFQLTNHA 401

  Fly   557 VLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSA 611
            ||:|||| :|.....|   |||||||||..|||:||:|:.||.:.|.:..:|.||
Frog   402 VLLVGYG-TDQQTGEK---YWIVKNSWGESWGEKGYFRIRRGTDECAIESIAVSA 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	4/34 (12%)
		Peptidase_C1A	395..611	CDD:239068	85/236 (36%)
ctsc	XP_012812143.2	CathepsinC_exc	20..136	CDD:400909
ctsc	XP_012812143.2	Peptidase_C1A_CathepsinC	226..455	CDD:239112	88/239 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910