DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctsba

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_998501.1	Gene:	ctsba / 406645	ZFINID:	ZDB-GENE-040426-2650	Length:	330	Species:	Danio rerio

Alignment Length:	301	Identity:	78/301 - (25%)
Similarity:	125/301 - (41%)	Gaps:	63/301 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 FADMTSSEYKERTGLWQRDEAKATGGSAAVVPAY-HG-ELPKEFD----WRQKDAVTQVKNQGSC 415
            |.|:..|..|:..|.:.:      |....|:..| .| :|||.||    |.....:.::::||||
Zfish    46 FRDVDYSYVKKLCGTFLK------GPKLPVMVQYTEGLKLPKNFDAREQWPNCPTLKEIRDQGSC 104

  Fly   416 GSCWAFSVTGNIEGLYAVKTGELK---EFSEQELLD-CDTTDSACNGGLMDNAYK--AIKDI--G 472
            ||||||.....|.....:.: :.|   |.|.|:||. ||:....||||....|:.  |.:.:  |
Zfish   105 GSCWAFGAAEAISDRVCIHS-DAKVSVEISSQDLLTCCDSCGMGCNGGYPSAAWDFWATEGLVTG 168

  Fly   473 GLEYEAEY---PYKAKKNQCHFNRTL-----------------------SHVQVAGF----VDLP 507
            || |.:..   ||..:..:.|.|.:.                       |:.|...|    ..:|
Zfish   169 GL-YNSHIGCRPYTIEPCEHHVNGSRPPCSGEGGDTPNCDMKCEPGYSPSYKQDKHFGKTSYSVP 232

  Fly   508 KGNETAMQEWLLANGPISIGINA-NAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFH 571
            ....:.|.| |..|||:...... .....|:.||   ::.:.......|.:.::|:|..:
Zfish   233 SNQNSIMAE-LFKNGPVEGAFTVYEDFLLYKSGV---YQHMSGSPVGGHAIKILGWGEEN----- 288

  Fly   572 KTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSAV 612
             .:|||:..|||...||:.||:::.||::.||:.....:.:
Zfish   289 -GVPYWLAANSWNTDWGDNGYFKILRGEDHCGIESEIVAGI 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	3/7 (43%)
		Peptidase_C1A	395..611	CDD:239068	68/258 (26%)
ctsba	NP_998501.1	Propeptide_C1	25..64	CDD:285358	5/23 (22%)
ctsba	NP_998501.1	Peptidase_C1A_CathepsinB	80..327	CDD:239111	68/258 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810