DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctsc

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_999887.1	Gene:	ctsc / 368704	ZFINID:	ZDB-GENE-030619-9	Length:	455	Species:	Danio rerio

Alignment Length:	330	Identity:	93/330 - (28%)
Similarity:	156/330 - (47%)	Gaps:	54/330 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 RFGRRYVSTAERQMRLRI-FRQNLKTIEELNANEMGSAKYGITEFADMTSSEYKERTGLWQRDEA 377
            |..||::...|.::.::: :..|:..::|:|:.:           ...|::.|.....|...:..
Zfish   142 RVDRRHMLGFEHRLLMKLPYTNNMMFVDEINSVQ-----------KSWTATAYSFHETLSIHEML 195

  Fly   378 KATGGSAAVVP-------------AYHGELPKEFDWRQKDA---VTQVKNQGSCGSCWAFSVTGN 426
            :.:||.|:.:|             |..| ||:.:|||..:.   |:.|:||..||||::|:..|.
Zfish   196 RRSGGPASRIPRRVRPVTVAADSKAASG-LPQHWDWRNVNGVNFVSPVRNQAQCGSCYSFATMGM 259

  Fly   427 IEGLYAVKTGELKE--FSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQC 489
            :|....::|...::  ||.|:::.|......|:||......|.|:|.|.:|.:. :||....:.|
Zfish   260 LEARVRIQTNNTQQPVFSPQQVVSCSQYSQGCDGGFPYLIGKYIQDFGIVEEDC-FPYTGSDSPC 323

  Fly   490 HFNRTLS------HVQVAGFVDLPKG-NETAMQEWLLANGPISIGINANA-MQFYRGGVSHPWKA 546
            :.....:      :..|.||..   | :|:||...|:.|||:.:.:.... ...|:.|:.| ...
Zfish   324 NLPAKCTKYYASDYHYVGGFYG---GCSESAMMLELVKNGPMGVALEVYPDFMNYKEGIYH-HTG 384

  Fly   547 LCSKKN----LDHGVLVVGYGVSDYPNFHKT-LPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSE 606
            |....|    .:|.||:||||     ..||| ..|||||||||..|||.|::|:.||.:.|.:..
Zfish   385 LRDANNPFELTNHAVLLVGYG-----QCHKTGEKYWIVKNSWGSGWGENGFFRIRRGTDECAIES 444

  Fly   607 MATSA 611
            :|.:|
Zfish   445 IAVAA 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	8/51 (16%)
		Peptidase_C1A	395..611	CDD:239068	75/233 (32%)
ctsc	NP_999887.1	CathepsinC_exc	20..132	CDD:285926
ctsc	NP_999887.1	Peptidase_C1A_CathepsinC	224..452	CDD:239112	77/236 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910