DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Cp1

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	129/325 - (39%)
Similarity:	186/325 - (57%)	Gaps:	27/325 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 DKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELN---ANEMGSAKYGITEFADMTSS 363
            |.|...::.|::...:.|....|.:.||:||.:|...|.:.|   |....|.|..:.::||:...
  Fly    53 DVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHH 117

  Fly   364 EYKE---------RTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCW 419
            |:::         ...|...||  :..|...:.|| |..|||..|||.|.|||.||:||.|||||
  Fly   118 EFRQLMNGFNYTLHKQLRAADE--SFKGVTFISPA-HVTLPKSVDWRTKGAVTAVKDQGHCGSCW 179

  Fly   420 AFSVTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAIKDIGGLEYEAEYPY 482
            |||.||.:||.:..|:|.|...|||.|:||.|.  ::.|||||||||::.|||.||::.|..|||
  Fly   180 AFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPY 244

  Fly   483 KAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINAN--AMQFYRGGVSHPWK 545
            :|..:.||||:........||.|:|:|:|..|.|.:...||:|:.|:|:  :.|||..||.:  :
  Fly   245 EAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYN--E 307

  Fly   546 ALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVSEMAT 609
            ..|..:||||||||||:|..:...     .||:||||||..||::|:.::.|. :|.||::..::
  Fly   308 PQCDAQNLDHGVLVVGFGTDESGE-----DYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASS 367

Fly 610 609
Fly 368 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	15/59 (25%)
		Peptidase_C1A	395..611	CDD:239068	103/220 (47%)
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	15/58 (26%)
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	104/221 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D71650at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.650