DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsf

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001029282.1	Gene:	Ctsf / 361704	RGDID:	1308181	Length:	462	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	174/467 - (37%)
Similarity:	246/467 - (52%)	Gaps:	74/467 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 KPY--DEEAAKAQLQK-------SLDKLTAGEGPHYKIV--KVYSASRQVDSGILTRIDADLIDG 244
            ||:  ||:|.....|:       :||....|.....:.|  .|:...|:...|.|..::|.|
  Rat    25 KPWADDEQAWSLSSQELLAPARFALDMYNYGRTAVTRAVLGAVHGRVRRAGRGSLFSLEATL--- 86

  Fly   245 SEEQHRC---------------------IVDIWTKVWVRKDEHEITFKCRNQPVVQARHTRSVEW 288
              |:..|                     :.::...:.:|||       |  .| |.|:.|.|
  Rat    87 --EEPPCNDPLVCLHPETKKTMLCSFEVLEELKEHLLLRKD-------C--SP-VNAKVTES--- 136

  Fly   289 AEKKTHKKHSHRFD----------KVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELN 343
             ..:|.:......|          |:..||..|...:.|.|.|..|.|.||.:|.:|:...:::.
  Rat   137 -GNETFRAFLPMLDKDPLPQDFSVKMATLFKDFMTTYNRTYESREEAQWRLTVFARNMIRAQKIQ 200

  Fly   344 ANEMGSAKYGITEFADMTSSEYKE--RTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAV 406
            |.:.|:|:||||:|:|:|..|:..  ...|.|    |.:||..::..:.:...|.|:|||:|.||
  Rat   201 ALDRGTAQYGITKFSDLTEEEFHTIYLNPLLQ----KESGGKMSLAKSINDLAPPEWDWRKKGAV 261

  Fly   407 TQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDI 471
            |:||:||.||||||||||||:||.:.:..|.|...|||||||||..|.||.|||..|||.|||::
  Rat   262 TEVKDQGMCGSCWAFSVTGNVEGQWFLNRGTLLSLSEQELLDCDKMDKACMGGLPSNAYTAIKNL 326

  Fly   472 GGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQFY 536
            ||||.|.:|.|:.....|:|:..::.|.:...|:|.: :|..:..||...||||:.|||..||||
  Rat   327 GGLETEDDYGYQGHVQACNFSTQMAKVYINDSVELSR-DENKIAAWLAQKGPISVAINAFGMQFY 390

  Fly   537 RGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNT 601
            |.|::||::.|||...:||.||:||||      ....:|||.:|||||..|||:|||.:|||...
  Rat   391 RHGIAHPFRPLCSPWFIDHAVLLVGYG------NRSNIPYWAIKNSWGRDWGEEGYYYLYRGSGA 449

  Fly   602 CGVSEMATSAVL 613
            |||:.||:|||:
  Rat   450 CGVNTMASSAVV 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856	19/107 (18%)
		Inhibitor_I29	308..365	CDD:285458	21/56 (38%)
		Peptidase_C1A	395..611	CDD:239068	113/215 (53%)
Ctsf	NP_001029282.1	Inhibitor_I29	165..221	CDD:214853	21/55 (38%)
Ctsf	NP_001029282.1	Peptidase_C1	249..460	CDD:395062	114/217 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343572
Domainoid	1	1.000	245	1.000	Domainoid score	I2122
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2703
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264766at2759
OrthoFinder	1	1.000	-	-		FOG0007524
OrthoInspector	1	1.000	-	-		oto97647
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	1	1.100	-	-	LDO	PTHR12411
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3186
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760