DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctss2.2

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_009290599.1	Gene:	ctss2.2 / 337572	ZFINID:	ZDB-GENE-050626-55	Length:	337	Species:	Danio rerio

Alignment Length:	330	Identity:	116/330 - (35%)
Similarity:	172/330 - (52%)	Gaps:	40/330 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 SHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLK--TIEELNANEMGSAKY--GITEFA 358
            :|....:|..:..::.:..:.|....|...|..::.:||:  .|..|.|: ||...|  .|...|
Zfish    24 AHFNTNLDQHWELWKKKHVKLYSCEDEEVGRRELWERNLELIAIHNLEAS-MGMHSYDLAINHMA 87

  Fly   359 DMTSSEYKERTGL------WQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGS 417
            |||:.|..:...:      ::|..|:....|.|||       |...|||.|..||.|||||:|||
Zfish    88 DMTTEEILQTLAVTRVPPGFKRPTAEYVSSSFAVV-------PDTLDWRDKGYVTSVKNQGACGS 145

  Fly   418 CWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAIKDIGGLEYEAEY 480
            |||||..|.:||.....||:|.:.|.|.|:||.:.  :..||||.|..|::.:.|.||::.|:.|
Zfish   146 CWAFSSVGALEGQLMKTTGKLVDLSPQNLVDCSSKYGNLGCNGGYMSQAFQYVIDNGGIDSESSY 210

  Fly   481 PYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQ--FYRGGV-SH 542
            ||:..:..|.::.:........:..:.:|:|.|::|.|...||:|:.|:|...|  |||.|| ..
Zfish   211 PYQGTQGSCRYDPSQRAANCTSYKFVSQGDEQALKEALANIGPVSVAIDATRPQFIFYRSGVYDD 275

  Fly   543 PWKALCSKKNLDHGVLVVGYGVSDYPNFHKTL---PYWIVKNSWGPRWGEQGYYRVYRG-DNTCG 603
            |   .|::| ::||||.||||         ||   .||:||||||..:|:.||.|:.|. :|.||
Zfish   276 P---SCTQK-VNHGVLAVGYG---------TLSGQDYWLVKNSWGAGFGDGGYIRIARNKNNMCG 327

  Fly   604 VSEMA 608
            ::..|
Zfish   328 IASEA 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	16/60 (27%)
		Peptidase_C1A	395..611	CDD:239068	91/223 (41%)
ctss2.2	XP_009290599.1	Inhibitor_I29	34..93	CDD:214853	16/59 (27%)
ctss2.2	XP_009290599.1	Peptidase_C1	122..336	CDD:278538	92/231 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.710